55860-35-0

Usage

Uses

Used in Organic Synthesis:
4-Acetyl-2-methyl benzoic acid is used as an organic synthesis intermediate for the production of various chemical compounds. Its versatile structure allows it to be a key component in the synthesis of a wide range of organic molecules, contributing to the development of new materials and substances.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-acetyl-2-methyl benzoic acid is utilized as a pharmaceutical intermediate. It plays a crucial role in the development of new drugs and medicines, particularly in the synthesis of active pharmaceutical ingredients (APIs) that target specific medical conditions.
Used in Laboratory Research and Development:
4-Acetyl-2-methyl benzoic acid is also employed in laboratory research and development processes. It serves as a valuable compound for scientists and researchers to study its properties, reactivity, and potential applications in various fields, including chemistry, biology, and materials science.
Used in Chemical Production Processes:
4-acetyl-2-methyl benzoic acid is further used in chemical production processes, where it can be transformed into other valuable chemicals or materials. Its involvement in these processes highlights the importance of 4-acetyl-2-methyl benzoic acid as a building block for the chemical industry.

Upstream product

• 10311-74-7 2,2'-dimethyl-stilbene 
• 5294-03-1 di-o-tolylethyne 
• 57542-70-8 α,α'-dibromo-2,2'-dimethyl-bibenzyl 
• 1530-36-5 [(2-methylphenyl)methyl]triphenylphosphonium bromide 
• 3637-01-2 3,4-dimethylacetophenone 
• 1138444-80-0 3-methyl-4-cyanoacetophenone 
• 95-52-3 2-Fluorotoluene 
• 369-32-4 1-(4-fluoro-3-methylphenyl)ethanone 
• 111-34-2 -butyl vinyl ether 
• 68837-59-2 4-bromo-2-methylbenzoic acid 
• 201230-82-2 carbon monoxide 
• 37074-40-1 1-(4-bromo-3-methylphenyl)ethan-1-one 

Downstream Products

• 1095275-09-4 4-(3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybutanoyl)-2-methylbenzoic acid diethylamine salt 
• 1095275-08-3 4-(3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybutanoyl)-2-methylbenzoate triethylamine 
• 1095275-07-2 4-(3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybutanoyl)-2-methylbenzoic acid 
• 1095275-05-0 4-acetyl-2-methyl benzoyl chloride 
• 1332628-87-1 4-acetyl-2-methyl-N-thietan-3-ylbenzamide 
• 1332628-88-2 4-[(E)-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-but-2-enoyl]-2-methyl-N-thietan-3-yl-benzamide 
• 1332628-94-0 4-acetyl-2-methyl-N-(1,1-dioxidethietan-3-yl)benzamide 
• 1332628-95-1 4-[(E)-3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-2-enoyl]-2-methyl-N-(1,1-dioxidethietan-3-yl)benzamide 
• 1391709-90-2 4-(5-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-3-yl)-2-methylbenzohydrazide 
• 1391709-89-9 4-(5-(2-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl)-2-methylbenzohydrazide 
• 1391709-88-8 4-(4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)-2-methylbenzohydrazide 
• 1391709-87-7 4-(4,5-dihydro-5-phenyl-1H-pyrazol-3-yl)-2-methylbenzohydrazide 
• 1391709-86-6 4-(4,5-dihydro-5-(4-nitrophenyl)-1H-pyrazol-3-yl)-2-methylbenzohydrazide 
• 1391709-85-5 4-[5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]-2-methylbenzohydrazide 

Relevant academic research and scientific papers

Method for synthesizing methyl 2-methyl-4-acetyl benzoate

The invention provides a method for synthesizing methyl 2-methyl-4-acetyl benzoate. The method comprises the following steps: (1) adding an acylating reagent to a solution with dissolved 2-fluorotoluene, and carrying out an acylation reaction so as to obtain 4-fluoro-3-methylacetophenone; (2) dissolving the obtained 4-fluoro-3-methylacetophenone, adding a cyanation reagent, and carrying out a cyanation reaction so as to obtain 3-methyl-4-cyanoacetophenone; (3) adding acid to the 3-methyl-4-cyanoacetophenone, and carrying out a hydrolysis reaction so as to obtain 2-methyl-4-acetylbenzoic acid;and (4) adding methanol to the 2-methyl-4-acetylbenzoic acid, and carrying out an esterification reaction so as to obtain methyl 2-methyl-4-acetyl benzoate. The method has simple operation, a high reaction yield, easily purchasable reagents and instruments and low cost, and is feasible in specific practical application.

PROCESS FOR THE PREPARATION OF ISOXAZOLINE DERIVATIVES

The present invention relates to processes for the preparation of compounds of formula IB wherein A1, A2, A3, A4, L, Y1, Y2, R1, R2, R3, R4 and R5 are as defined in the claims, comprising reacting a compound of formula (II) wherein Y1, Y2, L, A1, A2, R1, R2, R3, R4 and R5 are as defined for the compound of formula (I); with hydroxylamine in the presence of water, a base and a chiral phase transfer catalyst, which chiral phase transfer catalyst is a quinine derivative. The invention also relates to compounds of formula IB and enantiomerically enriched mixtures comprising compounds of formula IB.

METHOD FOR PRODUCTION OF 3-HYDROXYPROPAN-1-ONE COMPOUND, METHOD FOR PRODUCTION OF 2-PROPEN-1-ONE COMPOUND, AND METHOD FOR PRODUCTION OF ISOXAZOLINE COMPOUND

There is provided a novel intermediate for producing pesticides. A method for producing 1,3-bis(substituted phenyl)-3-substituted-3-hydroxypropan-1-one compound of Formula (3) comprises reacting an aromatic ketone compound of Formula (4) and a substituted acetophenone compound of Formula (5) as starting raw materials in an organic solvent or water in the presence or absence of an additive in the presence of a base in a suspended state. A method for producing 1,3-bis(substituted phenyl)-3-substituted-2-propen-2-one compound of Formula (2) comprises dehydrating the compound of Formula (3). A method for producing compound (2) in one step comprises reacting compound (4) and compound (5) to obtain compound (3). Further, a method for producing an isoxazoline compound of Formula (1) comprises reacting compound (2) and a hydroxylamine in an aliphatic or an aromatic hydrocarbon solvent which is optionally substituted by a halogen atom by adding an additive selected from a phase-transfer catalyst, a C1-C6 alcohol and an aprotic polar solvent in the presence of a base and water.

Selective oxidation of acetophenones bearing various functional groups to benzoic acid derivatives with molecular oxygen

Acetophenones substituted by alkyl, alkoxy, acetoxy, and halogen groups were selectively oxidized with molecular oxygen to the corresponding benzoic acids by using the N,N',N"-trihydroxyisocyanuric acid (THICA)/cobalt(II) acetate [Co(OAc)2] and THICA/Co(OAc)2/manganese(II) acetate.