37074-40-1

Usage

Uses

Used in Pharmaceutical Synthesis:
4'-Bromo-3'-methylacetophenone is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to be readily modified and incorporated into complex molecular structures, contributing to the development of new drugs.
Used in Organic Synthesis:
4'-Bromo-3'-methylacetophenone is utilized as a versatile building block in organic synthesis, particularly in the preparation of heterocyclic compounds, which are important in the creation of new materials and organic compounds with specific properties.
Used in Flavor and Fragrance Industry:
4'-Bromo-3'-methylacetophenone is used as a flavor and fragrance ingredient in the food and cosmetic industries, capitalizing on its aromatic properties to enhance the sensory experience of products.
Used in Medicinal Chemistry:
4'-Bromo-3'-methylacetophenone is applied in medicinal chemistry for its potential to be part of drug discovery and development processes, given its structural features that allow for diverse chemical reactions and modifications.
Used in Agrochemicals:
4'-Bromo-3'-methylacetophenone finds use in the agrochemical industry, potentially contributing to the development of new pesticides or other agricultural chemicals due to its reactivity and structural attributes.
Used in Material Science:
In the field of material science, 4'-Bromo-3'-methylacetophenone is employed for its potential role in creating new materials with unique properties, leveraging its chemical reactivity and structural characteristics.

InChI:InChI=1/C9H9BrO/c1-6-5-8(7(2)11)3-4-9(6)10/h3-5H,1-2H3

Upstream product

• 41963-20-6 4-bromo-3-methylbenzonirtile 
• 40664-73-1 4'-acetylamino-3'-methyl-acetophenone 
• 120-66-1 N-(2-methylphenyl)acetamide 
• 95-53-4 o-toluidine 
• 75-16-1 methylmagnesium bromide 
• 170230-01-0 4-bromo-N-methoxy-3,N-dimethylbenzamide 
• 51930-77-9 1-(4-bromo-3-methylphenyl)ethan-1-ol 
• 78775-11-8 3-methyl-4-bromobenzaldehyde 
• 917-54-4 methyllithium 
• 7697-28-1 4-bromo-3-methylbenzoic acid 
• 43230-11-1 4'-amino-3'-methyl-acetophenone 
• 6933-10-4 amino-5-bromo-2-toluene 
• 95-46-5 2-methylphenyl bromide 
• 75-36-5 acetyl chloride 

Downstream Products

• 6939-93-1 4-bromo-isophthalic acid 
• 7697-28-1 4-bromo-3-methylbenzoic acid 
• 51930-77-9 1-(4-bromo-3-methylphenyl)ethan-1-ol 
• 792917-14-7 (4-bromo-3-methyl-phenyl)-acetic acid amide 
• 90841-15-9 1-bromo-4-isopropenyl-2-methyl-benzene 
• 90560-90-0 4-ethyl-1-bromo-2-methyl-benzene 
• 3114-08-7 2-bromo-1-(4-bromo-3-methylphenyl)ethan-1-one 
• 55860-35-0 4-acetyl-2-methyl benzoic acid 
• 1321848-45-6 C₁₇H₁₇NO₂ 
• 1321848-53-6 C₁₇H₁₅Br₂NO₂ 
• 1321848-43-4 C₁₅H₂₁BO₃ 
• 1036715-60-2 4-acetyl-2-methylbenzoic acid methyl ester 
• 90560-53-5 1-bromo-2-methyl-4-vinyl-benzene 

Relevant academic research and scientific papers

Preparation method of velpatasvir intermediate

The invention provides a preparation method of a velpatasvir intermediate. According to the preparation method, ortho-toluidine is taken as an initial raw material, amino acetylation protection, Friedel-Crafts acylation, deamination protection, diazotization, and bromination are adopted so as to obtain 3-bromomethyl-4-bromoacetophenone; and alkylation with 7-hydroxy-1-tetralone, intramolecular coupling, and bromination are adopted so as to obtain 9-bromo-3-(2-bromoacetyl)-10, 11-dihydro-5H-benzo[d]naphtho[2,3-b]pyran-8(9H)-one. The yield and the purity of the velpatasvir intermediate preparedvia the preparation method are high, cost is low, and large size production is convenient to realize.

PROCESS FOR THE PREPARATION OF VELPATASVIR

The present disclosure provides a process for the preparation of velpatasvir intermediates of formula 5. The intermediates may be further converted to velpatasvir or pharmaceutically acceptable salts thereof.

ISOQUINOLINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

A compound of formula (I): wherein the substituents are as defined in the description. Medicinal products containing the same which are useful in treating or preventing pathologies which are the result of activation of the RhoA/ROCK pathway and phosphorylation of the myosin light chain.

2-ACYLAMINOTHIAZOLES FOR THE TREATMENT OF CANCER

The present invention relates to inhibitors of the oncogenic protein kinase ALK of formula (I) as herein described and pharmaceutical compositions thereof. The compounds of formula (I) are useful in the preparation of a medicament, in particular for the treatment of cancer.

Modulators of methyl modifying enzymes, compositions and uses thereof

Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.

MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF

Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein

NOVEL INHIBITORS OF HEPATITIS C VIRUS

The invention provides compounds of formula (I): wherein the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are inhibitors of replication of the hepatitis C virus. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat hepatitis C viral infections, and processes and intermediates useful for preparing such compounds.

HEPATITIS C INHIBITOR COMPOUNDS

Compounds of Formula (I): wherein R1, R2, RA, RB, Z1, Z2, Z3, Z4, Z5 and Z6 are defined herein. The compounds are useful as inhibitors of the function of NS5A protein encoded by HCV for the treatment of hepatitis C viral infection.

METHOD FOR PRODUCTION OF 3-HYDROXYPROPAN-1-ONE COMPOUND, METHOD FOR PRODUCTION OF 2-PROPEN-1-ONE COMPOUND, AND METHOD FOR PRODUCTION OF ISOXAZOLINE COMPOUND

There is provided a novel intermediate for producing pesticides. A method for producing 1,3-bis(substituted phenyl)-3-substituted-3-hydroxypropan-1-one compound of Formula (3) comprises reacting an aromatic ketone compound of Formula (4) and a substituted acetophenone compound of Formula (5) as starting raw materials in an organic solvent or water in the presence or absence of an additive in the presence of a base in a suspended state. A method for producing 1,3-bis(substituted phenyl)-3-substituted-2-propen-2-one compound of Formula (2) comprises dehydrating the compound of Formula (3). A method for producing compound (2) in one step comprises reacting compound (4) and compound (5) to obtain compound (3). Further, a method for producing an isoxazoline compound of Formula (1) comprises reacting compound (2) and a hydroxylamine in an aliphatic or an aromatic hydrocarbon solvent which is optionally substituted by a halogen atom by adding an additive selected from a phase-transfer catalyst, a C1-C6 alcohol and an aprotic polar solvent in the presence of a base and water.

DIHYDROIMIDAZOTHIAZOLE DERIVATIVES

Compounds of formula (I): or pharmaceutically acceptable salts thereof, exhibit 5-HT1A agonism in addition to noradrenaline reuptake inhibition and optionally also 5-HT reuptake inhibition are useful for the treatment of obesity.