5588-87-4

Usage

Uses

Used in Pharmaceutical Synthesis:
Benz[e]isatin is used as a building block for the synthesis of various pharmaceutical compounds, particularly for the development of anticancer and antimicrobial agents. Its chemical structure allows for the creation of diverse drug candidates that can target specific biological pathways.
Used in Antioxidant and Anti-Inflammatory Applications:
Due to its antioxidant and anti-inflammatory properties, Benz[e]isatin is used in the development of therapeutic agents aimed at treating conditions where oxidative stress and inflammation play a significant role in disease progression.
Used in Neurological Disorder Treatment:
Benz[e]isatin is used as a potent inhibitor of the enzyme monoamine oxidase, making it a potential candidate for the treatment of neurological disorders such as Parkinson's disease and depression. Its ability to modulate monoamine levels could provide therapeutic benefits in managing these conditions.
Used in Research and Development:
In the scientific community, Benz[e]isatin serves as a valuable compound for research and development, particularly in exploring its chemical properties and potential interactions with biological systems, which can lead to the discovery of new applications and therapeutic uses.

InChI:InChI=1/C12H7NO2/c14-11-10-8-4-2-1-3-7(8)5-6-9(10)13-12(11)15/h1-6H,(H,13,14,15)

Upstream product

• 91-59-8 naphthalen-2-ylamine 
• 609-09-6 Diethyl ketomalonate 
• 107976-74-9 3H-benz[e]indole-1,2-dione-1-oxime 
• 7664-93-9 sulfuric acid 
• 64-17-5 ethanol 
• 7647-01-0 hydrogenchloride 
• 7446-70-0 aluminium trichloride 
• 159788-24-6 [2]naphthyl-aminooxalyl chloride 
• 98-95-3 nitrobenzene 
• 131543-46-9 Glyoxal 
• 54673-30-2 3-phenyl-1,2,4-triazin-5-one 
• 6540-42-7 (2-amino-[1]naphthyl)-glyoxylic acid 

Downstream Products

• 479-41-4 indirubin 
• 5278-84-2 2-phenyl-4-carboxy-5,6-benzoquinoline 
• 79979-69-4 2-aminonaphthalene-1-carboxylic acid 
• 5278-86-4 3-(4-methoxy-phenyl)-benzo[f]quinoline-1-carboxylic acid 
• 6371-08-0 7,7'-dibromo-3H,3'H-[2,2']bi[benz[e]indolylidene]-1,1'-dione 
• 861087-97-0 2-benzoylamino-[1]naphthoic acid 
• 28707-41-7 3-biphenyl-4-yl-benzo[f]quinoline 
• 677290-81-2 2-[(phenylsulfonyl)amino]-1-naphthoic Acid 

Relevant academic research and scientific papers

Reactions of 1,2,4-Triazin-5(2H)-ones with Phenols and Aromatic Amines

1,2,4-Triazin-5(2H)-ones 1 react as well with phenols, resorinol and its dimethyl ethers, as with dimethyland diethylaniline, yielding 6-aryl-1,6-didydro-1,2,4-triazin-5(2H)-ones 2, 4-8, 12-15. Oxidation of the 1,6-dihydroadducts 2a,b gives the correspond

Ruthenium-Catalyzed Asymmetric Allylic Alkylation of Isatins

A new ruthenium-based catalytic system for branched-selective asymmetric allylic alkylation is disclosed and applied to the synthesis of chiral isatin derivatives. The catalyst, which is generated in situ from commercially available CpRu(MeCN)3PF6 and a BINOL-derived phosphoramidite, is both highly active (TON up to 180) and insensitive to air and moisture. Additionally, the N-alkylated isatins accessible using this methodology are versatile building blocks that are readily transformed into chiral analogs of achiral drug molecules.

COMPOUNDS FOR TREATMENT OF GLIOBLASTOMA

The present invention relates to compounds and methods for the treatment of glioblastoma, as well as to a pharmaceutical composition comprising said compounds. More specifically the invention relates to substituted quinoline derivatives having the formula (I), (II) or (III), and a pharmaceutical composition comprising said compounds for the treatment of cancer. (Formulae (I), (II), (III))

Double Carbonylation Using Glyoxal (HCOCOH): A Practical Copper-Promoted Synthesis of Isatins from Primary and Secondary Anilines

A novel double carbonylation process has been demonstrated with easily available HCOCOH (glyoxal) as the double carbonylation reagent. Simple CuCl2?2H2O (copper(II) chloride dihydrate) was used as the oxidant for this transformation. Under optimized reaction conditions, various primary and secondary anilines were double-carbonylated to afford their corresponding isatins (26 examples, up to 80% yields). (Figure presented.).

Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties

We have screened molecules for inhibition of MetAP2 as a novel approach toward antiangiogenesis and anticancer therapy using affinity selection/mass spectrometry (ASMS) employing MetAP2 loaded with Mn2+ as the active site metal. After a series

Sulfonamides having antiangiogenic and anticancer activity

Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.

Sulfonamides having antiangiogenic and anticancer activity

Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.

Sulfonamides having antiangiogenic and anticancer activity

Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating