5588-87-4

Basic information

• Product Name: Benz[e]isatin
• Synonyms: Benz[e]isatin;1H-Benz[e]indole-1,2(3H)-dione;4,5-Benzoisatin;1H-benzo[e]indole-1,2(3H)-dione
• CAS NO: 5588-87-4
• Molecular Formula: C₁₂H₇NO₂
• Molecular Weight: 197.19
• Mol File: 5588-87-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 248-249 °C
• Appearance: /
• Density: 1.391 g/cm³
• Refractive Index: 1.708
• PKA: 9.30±0.20(Predicted)
• CAS DataBase Reference: Benz[e]isatin(CAS DataBase Reference)
• NIST Chemistry Reference: Benz[e]isatin(5588-87-4)
• EPA Substance Registry System: Benz[e]isatin(5588-87-4)

Safety Data

• Hazardous Substances Data: 5588-87-4(Hazardous Substances Data)

Usage

General Description

Benz[e]isatin, also known as 2,3-dihydro-1H-indene-1,3(2H)-dione, is a heterocyclic compound with the molecular formula C12H8O2. It is a yellow crystalline solid that is insoluble in water but soluble in organic solvents. Benz[e]isatin is commonly used as a building block in the synthesis of various pharmaceutical compounds, including anticancer and antimicrobial agents. It also exhibits antioxidant and anti-inflammatory properties, making it a potential candidate for the development of new therapeutic agents. Additionally, Benz[e]isatin is known to act as a potent inhibitor of the enzyme monoamine oxidase, which makes it a potential candidate for the treatment of neurological disorders such as Parkinson's disease and depression.

InChI:InChI=1/C12H7NO2/c14-11-10-8-4-2-1-3-7(8)5-6-9(10)13-12(11)15/h1-6H,(H,13,14,15)

Upstream product

• 131543-46-9 Glyoxal 
• 91-59-8 naphthalen-2-ylamine 
• 7647-01-0 hydrogenchloride 
• 7446-70-0 aluminium trichloride 
• 159788-24-6 [2]naphthyl-aminooxalyl chloride 
• 98-95-3 nitrobenzene 
• 609-09-6 Diethyl ketomalonate 
• 64-17-5 ethanol 
• 107976-74-9 3H-benz[e]indole-1,2-dione-1-oxime 
• 7664-93-9 sulfuric acid 
• 54673-30-2 3-phenyl-1,2,4-triazin-5-one 
• 6540-42-7 (2-amino-[1]naphthyl)-glyoxylic acid 

Downstream Products

• 28707-41-7 3-biphenyl-4-yl-benzo[f]quinoline 
• 79979-69-4 2-aminonaphthalene-1-carboxylic acid 
• 5278-84-2 2-phenyl-4-carboxy-5,6-benzoquinoline 
• 6371-08-0 7,7'-dibromo-3H,3'H-[2,2']bi[benz[e]indolylidene]-1,1'-dione 
• 5278-86-4 3-(4-methoxy-phenyl)-benzo[f]quinoline-1-carboxylic acid 
• 479-41-4 indirubin 
• 861087-97-0 2-benzoylamino-[1]naphthoic acid 
• 677290-81-2 2-[(phenylsulfonyl)amino]-1-naphthoic Acid 

Relevant articles and documents

Reactions of 1,2,4-Triazin-5(2H)-ones with Phenols and Aromatic Amines

1,2,4-Triazin-5(2H)-ones 1 react as well with phenols, resorinol and its dimethyl ethers, as with dimethyland diethylaniline, yielding 6-aryl-1,6-didydro-1,2,4-triazin-5(2H)-ones 2, 4-8, 12-15. Oxidation of the 1,6-dihydroadducts 2a,b gives the correspond

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