55962-00-0Relevant articles and documents
Direct anomeric substitution of pyranyl esters using organocopper reagents
Bolitt,Mioskowski,Falck
, p. 6027 - 6030 (1989)
2-Substituted tetrahydropyrans were obtained by direct anomeric substitution of tetrahydropyranyl 2,4-dimethoxybenzoate, using Grignard-derived organocopper reagents.
Catalytic and metal-free intramolecular hydroalkoxylation of alkynes
Jean, Alexandre,Rouden, Jacques,Maddaluno, Jacques,De Paolis, Micha?l,Blanchet, Jér?me
, p. 534 - 537 (2019/01/19)
Benzyltrimethylammonium hydroxide act as an efficient metal-free catalyst for the intramolecular hydroalkoxylation of alkynes. Notably, the use of microwave irradiation allowed reaction to operate in only two minutes. Under optimized reaction conditions, linear alkynes bearing aryl and heteroaryl substituents were successfully cyclized with good level of stereoselectivity.
Cyclopropenium-activated cyclodehydration of diols
Kelly, Brendan D.,Lambert, Tristan H.
, p. 740 - 743 (2011/05/04)
The dehydrative cyclization of diols to cyclic ethers via cyclopropenium activation is described. Using 2,3-diphenylcyclopropene and methanesulfonic anhydride, a series of 1,4-and 1,5-diols are rapidly cyclized to furnish tetrahydrofurans and tetrahydropyrans in high yield. Eleven total substrates are shown, including a gram scale cyclization of a diterpene derivative.
