55985-68-7

Upstream product

• 2550-26-7 4-Phenyl-2-butanone 
• 75-36-5 acetyl chloride 
• 83947-56-2 4,4,5,5-tetramethyl-2-((E)-styryl)-[1,3,2]dioxaborolane 
• 22965-96-4 (Z)-3-bromo-4-phenyl-3-buten-2-one 
• 1896-62-4 (E)-benzalacetone 
• 78-94-4 methyl vinyl ketone 
• 62-53-3 aniline 
• 36004-04-3 ethyl (E)-1-phenylbut-1-en-3-ol 
• 1134-87-8 3-benzyl-pentane-2,4-dione 

Downstream Products

• 132868-04-3 3-benzyl-7-methoxy-2-methylindolizine 
• 62730-80-7 3-benzyl-4-hydroxy-4-phenyl-2-butanone 
• 62730-80-7 3-benzyl-4-hydroxy-4-phenyl-2-butanone 
• 129806-76-4 4-phenyl-3-(phenylsulfanyl)butan-2-one 
• 92287-63-3 4-phenyl-3-thiocyanato-2-butanone 
• 65248-93-3 5-benzyl-4-methyl-2-aminothiazole 
• 1125523-86-5 C₂₀H₂₄OS 
• 1069128-00-2 2-benzyl-5-tert-butyl-3-methylbenzo[b]thiophene 
• 1125522-07-7 3-[(2-methoxyphenyl)sulfanyl]-4-phenylbutan-2-one 
• 1069127-99-6 2-benzyl-7-methoxy-3-methylbenzo[b]thiophene 
• 1125518-57-1 2-benzyl-4-methoxy-3-methylbenzo[b]thiophene 
• 1069127-98-5 2-benzyl-6-methoxy-3-methylbenzo[b]thiophene 
• 1069128-01-3 2-benzyl-4,7-dimethoxy-3-methylbenzo[b]thiophene 
• 1069128-02-4 2-benzyl-3-methylnaphtho[1,2-b]thiophene 

Relevant academic research and scientific papers

Novel one-pot three-step reaction using supported reagents system: synthesis of 2-aminothiazoles

One-pot tandem three-step reaction has been developed by using supported reagents system. The synthesis of 2-aminothiazoles was selected for confirming the effectiveness of the method using supported reagents system. One-pot three-step reaction effectivel

Screening solution-phase combinatorial libraries using pulsed ultrafiltration/electrospray mass spectrometry

A method is described whereby a family of homologues is synthesized in a one-pot reaction, without isolation or purification, and the reaction mixture is screened using a competitive binding assay based on pulsed ultrafiltration/electrospray mass spectrom

Simple Method for sp2-sp3 and sp3-sp3 Carbon-Carbon Bond Activation in 2-Substituted 1,3-Diketones

Simple and efficient methods were developed for sp2-sp3 and sp3-sp3 C-C bond-activation reactions of 2-substituted 1,3-diketones. 3-Substituted 3-bromopentane-2,4-diones were deacylated in the presence of an aromatic compound and a silica gel supported Bronsted acid containing sulfonic groups. The carbocation formed by cleavage of the sp3-sp3 C-C bond of the dione alkylated the aromatic compound.

Iridium-catalyzed isomerization/bromination of allylic alcohols: Synthesis of α-bromocarbonyl compounds

α-Brominated ketones and aldehydes, with two adjacent electrophilic carbon atoms, are highly valuable synthetic intermediates in organic synthesis, however, their synthesis from unsymmetrical ketones is very challenging, and current methods suffer from low selectivity. We present a new, reliable, and efficient method for the synthesis of α-bromocarbonyl compounds in excellent yields and with excellent selectivities. Starting from allylic alcohols as the carbonyl precursors, the combination of a 1,3-hydrogen shift catalyzed by iridium(III) with an electrophilic bromination gives α-bromoketones and aldehydes in good to excellent yields. The selectivity of the process is determined by the structure of the starting allylic alcohol; thus, α-bromoketones formally derived from unsymmetrical ketones can be synthesized in a straightforward and selective manner. Synthon shuffle: An efficient and high-yielding synthetic route to prepare α-bromoketones and aldehydes is presented (see scheme, Cp=pentamethylcyclopentadienyl). The method relies on 1,3-hydrogen shift/bromination of allylic alcohols catalyzed by IrIII complexes. The products are obtained in excellent yields and as single constitutional isomers.

Enhancements of enantio and diastereoselectivities in reduction of (Z)-3-halo-4-phenyl-3-buten-2-one mediated by microorganisms in ionic liquid/water biphasic system

Reductions of (Z)-C6H5CHCXC(O)CH3 (X = Cl, Br) mediated by Saccharomyces cerevisiae, Candida albicans, Rhodotorula glutinis, Geotrichum candidum and Micrococcus luteus gave the corresponding halohydrins through consecutive

Convenient synthesis of α-bromo ketones by the Meerwein reaction

A simple and convenient procedure was proposed for the synthesis of 4-aryl-3-bromobutan-2-ones from methyl vinyl ketone and arenediazonium bromides under Meerwein reaction conditions. Pleiades Publishing, Ltd., 2012.

Oxidative bromination of ketones using ammonium bromide and oxone

A highly efficient, environmentally safe and economic method for selective α-monobromination of aralkyl, cyclic, acyclic, 1,3-diketones and β-keto esters and α,α-dibromination of 1,3-diketones and β-keto esters without catalyst is reported using ammonium bromide as a bromine source and oxone as an oxidant. The reaction proceeds at ambient temperature and yields range from moderate to excellent. Bromination of unsymmetrical ketones takes place at the less substituted α-position predominantly. Aromatisation of tetralones is also carried out with this reagent system.

Hydride transfer versus electron transfer in the reduction of 4-phenyl-3-halo-3-buten-2-ones mediated by Pichia stipitis

Reductions of (Z)-C6H5CHCXC(O)CH3 (X = Cl, Br) mediated by Pichia stipitis gave 4-phenylbutan-2-one through dehalogenation of intermediaries 3-halo-4-phenylbutan-2-one by an electron transfer mechanism. The addition of 1,3-dinitrobenzene avoids the dehalogenation and thus the corresponding (2S,3S)-halohydrins were obtained in excellent enantiomeric excesses by a hydride transfer mechanism. Irganox 1010 and 1076 were also used to inhibit the electron transfer mechanism. The obtained halohydrins are important chiral building blocks to obtain optically active epoxides and aminoalcohols.

Silica sulfuric acid-promoted deacylation of α-bromo-β-diketones

Novel deacylation of α-bromo-β-diketones using silica sulfuric acid (SSA) has been developed. Deacylation of 3- bromopentane-2,4-diones and 2-bromobutane-1,3-diones were carried out in the presence of SSA in dichloroethane under mild conditions to obtain the corresponding α-bromo ketones in good to excellent yields. SSA also promoted the FriedelCrafts type alkylation of benzene with 3-(sec-alkyl)-2,4-pentanediones to give the corresponding triarylmethanes in high yields in benzene.

N-THIAZOLYL-1, 2, 3, 4-TETRAHYDRO-6-ISOQUINOLINECARBOXAMIDE DERIVATIVES AS INHIBITORS OF STEAROYL COENZYME A DESATURASE

The present invention relates to substituted thiazole compounds of the formula (I) wherein Z represents (A), (B), (C) and (D) where * represents the point of attachment and salts thereof, to pharmaceutical compositions containing them and their use in med