56003-84-0

Upstream product

• 98-88-4 benzoyl chloride 
• 111-42-2 2,2'-iminobis[ethanol] 
• 532-55-8 Benzoyl isothiocyanate 
• 333-20-0 potassium thioacyanate 

Downstream Products

• 136724-34-0 bis(N-benzoyl-N',N'-di(2-hydroxyethyl)-thiourea)copper(II) 
• 136724-34-0 [1,1-bis(2-hydroxyethyl)-3-benzoylthioureato]-copper(II) 
• 165284-89-9 Pd(C₆H₅C(O)NC(S)N(CH₂CH₂OH)2)2 
• 265129-60-0 cis-(S-dimethylsulfoxide)(N,N-di(2-hydroxyethyl)-N'-(benzoyl)thioureato)chloroplatinum(II) 
• 165284-88-8 cis-bis(N,N-di(2-hydroxyethyl)-N'-(benzoyl)thioureato)platinum(II) 
• 136724-33-9 [1,1-bis(2-hydroxyethyl)-3-benzoylthioureato]-nickel(II) 
• 136724-33-9 bis(N-benzoyl-N',N'-di(2-hydroxyethyl)-thiourea)nickel(II) 

Relevant academic research and scientific papers

Synthesis and structural characterization of N-[4-(2-hydroxyethyl)-1,2,4- oxathiazinan-3-ylidene]-benzamide and its mercury(II) chloride adduct

The synthesis of N-[4-(2-hydroxyethyl)-1,2,4-oxathiazinan-3-ylidene]- benzamide (2a) and N-[4-(2-hydroxyethyl)-1,2,4-oxathiazinan-3-ylidene]-2- fluorobenzamide (2b) by oxidation of the corresponding 1,1-bis(2-hydroxyethyl)- 3-aroylthioureas with potassium

Bithiazole Inhibitors of Phosphatidylinositol 4-Kinase (PI4KIIIβ) as Broad-Spectrum Antivirals Blocking the Replication of SARS-CoV-2, Zika Virus, and Human Rhinoviruses

Over half a century since the description of the first antiviral drug, “old” re-emerging viruses and “new” emerging viruses still represent a serious threat to global health. Their high mutation rate and rapid selection of resistance toward common antiviral drugs, together with the increasing number of co-infections, make the war against viruses quite challenging. Herein we report a host-targeted approach, based on the inhibition of the lipid kinase PI4KIIIβ, as a promising strategy for inhibiting the replication of multiple viruses hijacking this protein. We show that bithiazole inhibitors of PI4KIIIβ block the replication of human rhinoviruses (hRV), Zika virus (ZIKV) and SARS-CoV-2 at low micromolar and sub-micromolar concentrations. However, while the anti-hRV/ZIKV activity can be directly linked to PI4KIIIβ inhibition, the role of PI4KIIIβ in SARS-CoV-2 entry/replication is debated.

ACCELERATORS FOR CURABLE COMPOSITIONS

Benzoylthiourea or benzoylthiourethane derivatives as cure accelerators for curable compositions are provided.

ACCELERATORS FOR TWO PART CURABLE COMPOSITIONS

Benzoylthiourea or benzoylthiourethane derivatives as cure accelerators for two part curable compositions are provided.

Fluorine hydrogen short contacts and hydrogen bonds in substituted benzamides

A series of fluorine substituted benzamides 1-10 was synthesised and investigated by spectroscopic methods (NMR, IR, MS) and X-ray structure analysis. The configuration of these compounds strongly depends on solvent, temperature and substitution pattern.