56145-24-5Relevant academic research and scientific papers
Antimicrobial Haloalkyl Heterocycle Compounds
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Page/Page column, (2014/04/17)
This application describes compounds useful as anti-microbial agents, including as antibacterial, disinfectant, antifungal, germicidal or antiviral agents.
Solventless lactam synthesis by intramolecular cyclizations of α-iminoester derivatives under microwave irradiation
Zradni, Fatima-Zohra,Hamelin, Jack,Derdour, Aicha
, p. 439 - 454 (2007/10/03)
We have previously reported a new synthesis of amides from esters and amines under microwave irradiation, offering much higher yields than those achieved with conventional heating [1]. We have now extended these studies to the ring closure of neat iminoes
Expeditious access to unprotected racemic pyroglutamic acids
Isaacson, Jerry,Gilley, Cynthia B.,Kobayashi, Yoshihisa
, p. 3913 - 3916 (2008/02/01)
(Chemical Equation Presented) A series of biologically intriguing pyroglutamic acids were synthesized in racemic form by employing indole-isonitrile and ammonium acetate in the Ugi 4-center-3-component reaction of γ-ketoacids.
Di- and tripeptide renin Inhibitors
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, (2008/06/13)
Di-and tripeptide enzyme inhibitors of the formula: and analogs thereof, which inhibit renin and are useful for treating various forms of renin-associated hypertension, hyperaldosteronism and congestive heart failure; compositions containing these renin-inhibitory peptides, optionally with other antihypertensive agents; and methods of treating hypertension, hyperaldosteronism or congestive heart failure or of establishing renin as a causative factor in these problems which employ these novel peptides.In addition, these renin inhibitors are useful in the inhibition of HIV protease, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines.
ALKYLATION OF SHIFF BASE ANIONS WITH ω-HALOGENO ESTERS: A LACTAM SYNTHESIS.
Mkhairi, A,Hamelin, J.
, p. 4435 - 4436 (2007/10/02)
Imine anions of α-aminoesters, obtained from NaH/DMSO are alkylated with ω-halogenoesters.Thermolysis of the alkylated compounds lead to functionnalized lactams.
