56149-29-2

Usage

InChI:InChI=1/C12H9ClN2O/c13-11-10(7-4-8-14-11)12(16)15-9-5-2-1-3-6-9/h1-8H,(H,15,16)

Upstream product

• 49609-84-9 2-Chloronicotinoyl chloride 
• 62-53-3 aniline 
• 100-46-9 benzylamine 
• 609-71-2 2-hydroxy-3-carboxypyridine 
• 2942-59-8 2-chloronicotinic acid 

Downstream Products

• 856211-83-1 2-(2-diethylamino-ethoxy)-nicotinic acid anilide 
• 879720-79-3 2-(2-dimethylamino-ethoxy)-nicotinic acid anilide 
• 56149-34-9 2-morpholin-4-yl-N-phenyl-nicotinamide 
• 125038-50-8 2-(4-Fluoro-phenoxy)-N-phenyl-nicotinamide 
• 52099-85-1 N-phenyl-2-phenylamino-3-pyridinecarboxamide 
• 879720-77-1 2-(2-piperidino-ethoxy)-nicotinic acid anilide 
• 859284-32-5 2-(2-dibutylamino-ethoxy)-nicotinic acid anilide 
• 104857-27-4 2-(phenyl)-3-oxoisothiazolo<5,4-b>pyridine 
• 139356-43-7 2-(2-Methyl-propane-2-sulfinyl)-N-phenyl-nicotinamide 
• 1385812-20-3 [2-NC₅H₃(3-CONHPh)Se]₂? 
• 1352083-11-4 3-cyclohexyl-2-phenyl-2H-pyrazolo[3,4-b]pyridine-6-carboxylic acid 
• 1352083-10-3 3-(cyclohex-1-en-1-yl)-2-phenyl-2H-pyrazolo[3,4-b]pyridine-6-carboxylic acid 
• 1352083-09-0 ethyl 3-chloro-2-phenyl-2H-pyrazolo[3,4-b]pyridine-6-carboxylate 
• 1352083-08-9 3-chloro-2-phenyl-2H-pyrazolo[3,4-b]pyridine-6-carboxylic acid 

Relevant academic research and scientific papers

Expedited access to thieno[3,2-c]quinolin-4(5H)-ones and benzo[h]-1,6-naphthyridin-5(6H)-ones via a continuous flow photocyclization method

A single-step continuous flow method has been developed that gives expedited access to complex heterocycles via an intramolecular photochemical cyclization. Herein we report the first examples of the photochemically-induced generation of thieno[3,2-c]quin

Benzoisothiazolone organo/copper-cocatalyzed redox dehydrative construction of amides and peptides from carboxylic acids using (EtO)3P as the reductant and O2 in air as the terminal oxidant

Carboxylic acids and amine/amino acid reactants can be converted to amides and peptides at neutral pH within 5-36 h at 50 °C using catalytic quantities of a redox-active benzoisothiazolone and a copper complex. These catalytic "oxidation-reduction condensation" reactions are carried out open to dry air using O2 as the terminal oxidant and a slight excess of triethyl phosphite as the reductant. Triethyl phosphate is the easily removed byproduct. These simple-to-run catalytic reactions provide practical and economical procedures for the acylative construction of C-N bonds.

ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF

The present application is related to compounds represented by Formula I, which are novel positive allosteric modulators of al nAChRs. The application also discloses the treatment of disorders that are responsive to enhancement of acetylcholine action on al nAChRs in a mammal by administering an effective amount of a compound of Formula I.

Synthesis, characterization, structures and antioxidant activity of nicotinoyl based organoselenium compounds

A series of nicotinoyl based organoselenium compounds, [2-NC 5H3(3-COOH)Se]2 (1), [2-NC5H 3(3-CO)Se-Se] (2), [2-NC5H3(3-CONH 2)Se]2 (3), [2-NC5H3(3-CONHPh)Se] 2 (4), [2-NC5H3(3-CONHpyrimidine)Se] 2 (5), [2-NC5H3(3-CONHPh)SeBr] (6) and [2-NC5H3(3-CONHPh)SeI] (7) have been synthesized and characterized by absorption, IR, NMR (1H, 13C{ 1H}, 77Se{1H}) and mass spectrometry. The crystal structures of [2-NC5H3(3-CO)Se-Se] (2) and [2-NC5H3(3-CONHPh)Se]2 (4) have been determined. The structure of (4) revealed the existence of two intra-molecular Se?X (X = O and N) interactions, as a result of this, C-Se-Se-C torsion angle is unusually large (180°). The GPx mimicking activity of these compounds has been evaluated using methods based on 1H NMR spectroscopy and HPLC. Free radical scavenging ability of the compounds was examined by DPPH and deoxyribose assay. All these studies indicated that the compound (3) not only showed highest GPx activity but also has a very good free radical scavenging ability thus making it a novel structure for development of nicotine based antioxidants.

VIRAL POLYMERASE INHIBITORS

The present invention relates to viral polymerase inhibitors of formula (I), salts, N-oxides, racemates, enantiomers and isomers thereof, processes for their preparation and their use in the treatment of Flaviviridae viral infections such as Hepatitis C v

Nine N-aryl-2-chloronicotinamides: Supramolecular structures in one, two and three dimensions

Structures are reported here for eight further substituted N-aryl-2-chloronicotinamides, 2-ClC5H3NCONHC 6H4X-4′. When X = H, compound (I) (C 12H9ClN2O), the molecules are linked

Nicotinamide Ethers: Novel Inhibitors of Calcium-Independent Phosphodiesterase and Rolipram Binding

The synthesis and biological properties of a series of nicotinamide ethers are described.These compounds, structurally novel calcium-independent phosphodiesterase inhibitors, also inhibit the binding of rolipram to rat brain membranes and reverse rese

A Convenient Synthesis of N-Aryl-1,2-dihydro-2-oxo-3-pyridinecarboxamides, N-Aryl-N-methyl-1,2-dihydro-2-oxo-3-pyrimidinecarboxamides and Their 1-Methyl (O-Methyl)-Derivatives

A new and versatile method for the preparation of the isonixine analogous, N-aryl-1,2-dihydro-2-oxo-3-pyridinecarboxamides and N-aryl-N-methyl-1,2-dihydro-2-oxo-3-pyridinecarboxamides is described via the selective chlorination of 2-hydroxynicotinic acid.