5625-98-9

Basic information

• Product Name: 2-MORPHOLINOACETAMIDE
• Synonyms: 2-MORPHOLINOACETAMIDE;2-(Morpholin-4-yl)acetamide
• CAS NO: 5625-98-9
• Molecular Formula: C₆H₁₂N₂O₂
• Molecular Weight: 144.17
• Mol File: 5625-98-9.mol

Chemical Properties

• Melting Point: 122 °C
• Boiling Point: 298.8 °C at 760 mmHg
• Flash Point: 134.5 °C
• Appearance: /
• Density: 1.135 g/cm³
• Vapor Pressure: 0.00124mmHg at 25°C
• Refractive Index: 1.487
• CAS DataBase Reference: 2-MORPHOLINOACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-MORPHOLINOACETAMIDE(5625-98-9)
• EPA Substance Registry System: 2-MORPHOLINOACETAMIDE(5625-98-9)

Safety Data

• Hazard Codes: C
• Hazardous Substances Data: 5625-98-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H12N2O2/c7-6(9)5-8-1-3-10-4-2-8/h1-5H2,(H2,7,9)

Upstream product

• 110-91-8 morpholine 
• 79-07-2 Chloroacetamide 
• 584-08-7 potassium carbonate 
• 683-57-8 bromo-acetic acid amide 
• 5807-02-3 4-morpholinoacetonitrile 

Downstream Products

• 1542259-10-8 3-chloro-N-(2-morpholinoethyl)-4-nitroaniline 
• 1542259-11-9 3-chloro-N¹-(2-morpholinoethyl)benzene-1,4-diamine 
• 1542258-29-6 3-(2-chloro-4-((2-morpholinoethyl)amino)phenyl)-2,6-dimethylpyrimidin-4(3H)-one 
• 1530-89-8 N-cyanomorpholine 
• 2038-03-1 4-(2-AMINOETHYL)MORPHOLINE 

Relevant articles and documents

Complexation, thermal and catalytic studies of N-substituted piperazine, morpholine and thiomorpholine with some metal ions

Several Cu(II), Pt(II) and Ni(II) complexes of N-substituted, piperazine (NN donor), morpholine (NO donor) and thiomorpholine (NS donor) derivatives were synthesized and their thermal behavior and catalytic activity in epoxidation reaction of cis-diphenylethylene were studied using oxygen sources NaOCl. The coordination compounds of Cu(II), Pt(II) and Ni(II) having general formula [MLCl]Cl, [ML2l]Cl2 or [ML]Cl2 with tetra coordinated geometry around metal ions have been isolated as solid. All the ligands and complexes were identified by spectroscopic methods and elemental analysis, magnetic measurements, electrical conductance and thermal analysis. A square planer structures have been proposed for all complexes. The thermal stability of the complexes discussed in terms of ligands donor atoms, geometry and central metal ions. The complexes have a similar thermal behavior for the selected metal ions. The thermogravimetric analyses suggest high thermal stability for most complexes followed by thermal decomposition in different steps. The decomposition processes were observed as water elimination, chloride anion removal and degradation of the organic ligands. Catalytic ability of the complexes were examined and found that all the complexes can effectively catalyze the epoxidation of cis-stilbene with NaOCl.

Novel and facile transformation of N,N-disubstituted glycylamides into corresponding cyanamides by using pentavalent iodine reagents in combination with tetraethylammonium bromide

Novel and facile transformation of N,N-disubstituted glycylamides into corresponding cyanamides using pentavalent iodine reagents and tetraethylammonium bromide is discussed. The advantages of this system are use of non toxic reagents, shorter reaction times and moderate to good yields. Georg Thieme Verlag Stuttgart.

STEREOSELECTIVE PRODUCTION OF HYDROXYAMIDE COMPOUNDS FROM CHIRAL ALPHA AMINO EPOXIDES

An efficient process for stereoselective preparation of a medicinally significant hydroxyamide compound of structural formula: STR1 comprises the addition of metalated amide enolates to chiral α-amino metalated epoxides. The hydroxyamide reaction products are useful as inhibitors of the HIV protease or of renin, or as intermediates in the preparation of inhibitors of the HIV protease or renin.

New isomeric classes of topically active ocular hypotensive carbonic anhydrase inhibitors: 5-Substituted thieno[2,3-b]thiophene-2-sulfonamides and 5-substituted theio[3,2-b]thiophene-2-sulfonamides

A series of 5-substituted thieno[2,3-b]- and thieno[3,2-b]thiophene-2-sulfonamides was prepared and evaluated for topical ocular hypotensive activity in glaucoma models. The 5-substituents were varied to maximize both inhibitory potency against carbonic anhydrase and water solubility. At the same time, these substituents were varied in order to obtain compounds with the appropriate pK(a) to minimize pigment binding in the iris. All of these variables were optimized in the best compound, 5-[[(methoxyethyl)](methoxyethyl)ethyl]amino]methyl]thieno[2,3-b] thiophene-2-sulfonamide hydrochloride (55).

Therapeutic agents

Compounds of formula I STR1 in which n=0 or 1; in which, when n=0, R1 is H, an alkyl, a cycloalkyl, a cycloalkylmethyl, an alkenyl or, an alkynyl group a heterocyclic ring or an optionally substituted phenyl ring or when n=1, R1 is H or an alkyl group; in which R2 and R3 are H or an alkyl group; in which A is a group of formula III in which W is an oxygen atom or a group of formula --S(O)m --, a group of formula --CR12 R13 --, a cycloalkylidene group or a cycloalkylene group; x is 0 or an integer from 1 to 5; y is 0 or an integer from 1 to 5. in which R4 is a carbocyclic ring, a heterocyclic ring, a cyano group, a carbamoyl group, an alkoxycarbonyl group, an amido group, an acyloxy group, a hydroxy group, a thiol group, or a group of formula --OR20, --SR20, --SOR20 or SO2 R20. in which R5, R6 and R7 are H, halo, trifluoromethyl, hydroxy, an alkyl group, an alkoxy or alkylthio group, phenyl or R5 and R6, together with the carbon atoms to which they are attached, form an optionally substituted second benzene ring; in which R8 and R9 are H or an alkyl group containing 1 to 3 carbon atoms; and pharmaceutically acceptable salts thereof have utility in the treatment of depression. Processes for their preparation and compositions containing them are disclosed.