56280-66-1

Upstream product

• 96-10-6 diethylaluminium chloride 
• 591-51-5 phenyllithium 

Downstream Products

• 112219-64-4 (2R,3R,4R,5S,6S)-3,4,5-tris(benzyloxy)-2-((benzyloxy)methyl)-6-phenyltetrahydro-2H-pyran 
• 116417-38-0 (2R,3R,4R,5S,6R)-3,4,5-tris(benzyloxy)-2-((benzyloxy)methyl)-6-phenyltetrahydro-2H-pyran 
• 25109-54-0 3,3,5-trimethyl-5-phenylcyclohexan-1-one 
• 18213-73-5 2,4-dimethoxy-6-phenyl-1,3,5-triazine 
• 1259553-09-7 (R)-1-bromo-2-(2-phenylbut-3-en-2-yl)benzene 
• 103-30-0 (E)-1,2-diphenyl-ethene 
• 1694-19-5 E-1-(phenyl)-2-(4'-methoxyphenyl)ethene 
• 4714-21-0 E-1-methyl-4-styryl-benzene 
• 718-25-2 (E)-4-fluorostilbene 
• 2840-87-1 (E)-1-styrylnaphthalene 
• 1149-56-0 (E)-4-trifluoromethylstilbene 

Relevant academic research and scientific papers

Quaternary carbon stereogenic centers through copper-catalyzed enantioselective allylic substitutions with readily accessible aryl- or heteroaryllithium reagents and aluminum chlorides

The case of the notorious aryls is solved: The first efficient catalytic and enantioselective method for allylic substitutions that furnish quaternary carbon stereogenic centers by additions of aryl- or heteroarylmetals is reported (see scheme). Highly site- and enantioselective processes begin with readily available organolithium reagents.

Copper-catalyzed asymmetric conjugate addition of aryl aluminum reagents to trisubstituted enones: Construction of aryl-substituted quaternary centers

(Chemical Equation Presented) Al be back: Novel aryl and alkenyl aluminum reagents are generated through a halogen/Li exchange-Li/Al transmetalation sequence. These aryl alanes are used in the copper-catalyzed asymmetric conjugate addition reaction to a variety of cyclic enones giving chiral aryl-substituted quaternary centers (see scheme). Both, electron-donating and electron-withdrawing groups give full conversion and very good ee values.