56280-66-1Relevant articles and documents
Quaternary carbon stereogenic centers through copper-catalyzed enantioselective allylic substitutions with readily accessible aryl- or heteroaryllithium reagents and aluminum chlorides
Gao, Fang,Lee, Yunmi,Mandai, Kyoko,Hoveyda, Amir H.
, p. 8370 - 8374 (2010/12/25)
The case of the notorious aryls is solved: The first efficient catalytic and enantioselective method for allylic substitutions that furnish quaternary carbon stereogenic centers by additions of aryl- or heteroarylmetals is reported (see scheme). Highly site- and enantioselective processes begin with readily available organolithium reagents.