18213-73-5

Basic information

• Product Name: 2,4-DIMETHOXY-6-PHENYL-1,3,5-TRIAZINE
• Synonyms: 2,4-DIMETHOXY-6-PHENYL-1,3,5-TRIAZINE;1,3,5-Triazine, 2,4-diMethoxy-6-phenyl-
• CAS NO: 18213-73-5
• Molecular Formula: C₁₁H₁₁N₃O₂
• Molecular Weight: 217.22
• Mol File: 18213-73-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 380.3°C at 760 mmHg
• Flash Point: 138.3°C
• Appearance: /
• Density: 1.19g/cm³
• Vapor Pressure: 1.2E-05mmHg at 25°C
• Refractive Index: 1.554
• CAS DataBase Reference: 2,4-DIMETHOXY-6-PHENYL-1,3,5-TRIAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIMETHOXY-6-PHENYL-1,3,5-TRIAZINE(18213-73-5)
• EPA Substance Registry System: 2,4-DIMETHOXY-6-PHENYL-1,3,5-TRIAZINE(18213-73-5)

Safety Data

• Hazardous Substances Data: 18213-73-5(Hazardous Substances Data)

Usage

General Description

2,4-DIMETHOXY-6-PHENYL-1,3,5-TRIAZINE is a chemical compound with the molecular formula C11H10N4O2. It is a triazine derivative with two methoxy groups and a phenyl group attached to the triazine ring. 2,4-DIMETHOXY-6-PHENYL-1,3,5-TRIAZINE is commonly used as a building block in organic synthesis reactions and can be found in various pharmaceutical and agrochemical products. It is known for its potential biological and pharmacological activities, making it an important compound in the field of medicinal chemistry. Additionally, 2,4-DIMETHOXY-6-PHENYL-1,3,5-TRIAZINE has been studied for its potential antioxidant and antimicrobial properties, which makes it a compound of interest in various research and development areas.

InChI:InChI=1/C11H11N3O2/c1-15-10-12-9(13-11(14-10)16-2)8-6-4-3-5-7-8/h3-7H,1-2H3

Upstream product

• 67-56-1 methanol 
• 1700-02-3 2,4-dichloro-6-phenyl-1,3,5-triazine 
• 3140-73-6 2-chloro-4,6-dimethoxy-1 ,3,5-triazine 
• 98-80-6 phenylboronic acid 
• 841-76-9 triphenylaluminium 
• 56280-66-1 diethyl(phenyl)aluminium 
• 1432754-92-1 1-(4,6-dimethoxy-1,3,5-triazin-2-yl)pyridine-4(1H)-one 
• 1432754-91-0 2,4-dimethoxy-6-(pyridine-2-yloxy)-1,3,5-triazine 
• 1383917-63-2 C₉H₁₅N₃O₂Te 
• 100-59-4 phenylmagnesium chloride 
• 100-58-3 phenylmagnesium bromide 

Relevant articles and documents

Nickel-catalyzed Suzuki-Miyaura coupling of heteroaryl ethers with arylboronic acids

Nickel-catalyzed Suzuki-Miyaura coupling of heteroaryl ethers with arylboronic acids was described. Selective activation of the phenol C-O bonds was achieved by converting them into the corresponding aryl 2,4-dimethoxy-1,3,5- triazine-6-yl ethers, in which aryl C-O bond could be selectively cleaved with inexpensive, air-stable NiCl2(dppf) as a catalyst. Coupling of these readily accessible heteroaryl ethers proved tolerant of extensive functional groups.

A mild robust generic protocol for the Suzuki reaction using an air stable catalyst

A mild but robust procedure has been developed as a first pass generic protocol for the Suzuki-Miyaura reaction. The protocol employs an air stable palladium pre-catalyst at low loading (1 mol %) in aqueous solvent mixtures at moderate temperature using potassium carbonate as base. Under these mild conditions, most aryl bromides will react with sterically and electronically demanding aryl boronic acids to give complete conversion to the product biphenyls in less than 1 h. Aryl chlorides are also fully converted in most cases either under identical conditions in 8-24 h, or in 2 h at elevated temperature. A further advantage of these mild conditions of moderate temperature, weak base and benign solvent is that sensitive functional groups and structural motifs are well tolerated. In addition, the lipophilic biphenyl products are readily isolated after a simple work-up procedure. These generic conditions are ideal for proof of transformation, and as the starting point for development and optimization of a specific process. The discovery and fine-tuning of this generic protocol will be presented, supported extensively by examples to illustrate its scope and utility.

Cp2Fe(PR2)2PdCl2 (R = i-Pr, t-Bu) complexes as air-stable catalysts for challenging Suzuki coupling reactions

(Chemical Equation Presented) The use of Cp2Fe(PR 2)2PdCl2 (R = i-Pr and t-Bu) in Suzuki coupling reactions were illustrated using a high throughput screening approach. The di-tbpfPdCl2 catalyst was shown to be the more active catalyst for unactivated and sterically challenging aryl chlorides. Comparison studies using the commercial catalysts dppfPdCl2, (Ph3P) 2PdCl2, (Cy3P)2PdCl2, DPEPhosPdCl2, dppbPdCl2, dppePdCl2, Pd(t-Bu3P)2, and [Pd-(μ-Br)(t-Bu3P)] 2 were also done for selected cases to demonstrate the superior activities of di-tbpfPdCl2 and di-isoppfPdCl2.