14385-54-7

Upstream product

• 183859-96-3 1-phenylethynyl-3,4-dihydronaphthalene-2-carboxaldehyde 
• 100-42-5 styrene 
• 573-97-7 1-bromo-2-naphthol 
• 947232-06-6 2-(β,β-dibromovinyl)-2-naphthol 
• 2996-92-1 phenyl trimethylsiloxane 
• 873-55-2 sodium benzenesulfonate 
• 135-19-3 β-naphthol 
• 1449-46-3 benzyltriphenylphosphonium bromide 
• 100-39-0 benzyl bromide 
• 100-51-6 benzyl alcohol 
• 536-74-3 phenylacetylene 
• 591-50-4 iodobenzene 
• 1396512-33-6 1-(phenylethynyl)naphthalen-2-ol 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 91388-11-3 formyl-1 phenyl-2 naphto<2,1-b>furanne 
• 91388-12-4 formyl-5 phenyl-2 naphto<2,1-b>furanne 
• 91388-13-5 acetyl-5 phenyl-2 naphto<2,1-b>furanne 

Relevant academic research and scientific papers

Selectfluor-Mediated Stereoselective [1 + 1 + 4 + 4] Dimerization of Styrylnaphthols

Stereoselective [1 + 1 + 4 + 4] dimerization of 1-styrylnaphthols has been developed by using Selectfluor as the oxidant for the first time. The reaction was compatible with various functional groups, giving a class of ethanodinaphtho[b,f][1,5]dioxocines

Metal-Free Oxidative Annulation of 2-Naphthols with Terminal Alkynes Affording 2-Arylnaphtho[2,1-b]furans

For the first time, the selective oxidative transformation of 2-naphthols with terminal alkynes is disclosed, which enables the straightforward synthesis of 2-arylnaphtho[2,1-b]furans in satisfactory yields under metal-free conditions. Mechanistic study s

Acid-catalyzed cleavage of C-C bonds enables atropaldehyde acetals as masked C2 electrophiles for organic synthesis

Acid-catalyzed tandem reactions of atropaldehyde acetals were established for the synthesis of three important molecules, 2,2-disubstituted indolin-3-ones, naphthofurans and stilbenes. The synthesis was realized using novel reaction cascades, which involved the same two initial steps: (i) SN2′ substitution, in which the atropaldehyde acted as an electrophile; and (ii) oxidative cleavage of the carbon-carbon bond of the generated phenylacetaldehyde-type products. Compared with literature methods, the present protocol not only avoided the use of expensive noble metal catalysts, but also enabled a simple operation.

Highly Efficient Synthesis of 2-Substituted Benzo[ b ]furan Derivatives from the Cross-Coupling Reactions of 2-Halobenzo[ b ]furans with Organoalane Reagents

A highly efficient and simple route for the synthesis of 2-substituted benzo[ b ]furans has been developed by palladium-catalyzed cross-coupling reaction of 2-halobenzo[ b ]furans with aryl, alkynyl, and alkylaluminum reagents. Various 2-aryl-, 2-alkynyl-, and 2-alkyl-substituted benzo[ b ]furan derivatives can be obtained in 23-97% isolated yields using 2-3 mol% PdCl 2/4-6 mol% XantPhos as the catalyst under mild reaction conditions. The aryls bearing electron-donating or electron-withdrawing groups in 2-halobenzo[ b ]furans gave products in 40-97% isolated yields. In addition, aluminum reagents containing thienyl, furanyl, trimethylsilanyl, and benzyl groups worked efficiently with 2-halobenzo[ b ]furans as well, and three bioactive molecules with 2-substituted benzo[ b ]furan skeleton were synthesized. Furthermore, the broad substrates scope and the typical maintenance of vigorous efficiency on gram scale make this protocol a potentially practical method to synthesize 2-substituted benzo[ b ]furan derivatives. On the basis of the experimental results, a possible catalytic cycle has been proposed.

Synthesis and biological evaluation of 2-arylbenzofuran derivatives as potential anti-Alzheimer’s disease agents

Alzheimer's disease (AD) is a type of progressive dementia caused by degeneration of the nervous system. A single target drug usually does not work well. Therefore, multi-target drugs are designed and developed so that one drug can specifically bind to mu

Silver-Catalyzed Nitration/Annulation of α-Alkynyl Arylols toward 3-Nitrated Benzofurans

A silver-catalyzed nitration/annulation of α-alkynyl arylols is reported by using tert-butyl nitrite (TBN) as a NO2 radical precursor, from which a set of 3-nitrated benzofurans were synthesized with moderate to good yields. This transformation

Fabrication of an amyloid fibril-palladium nanocomposite: A sustainable catalyst for C-H activation and the electrooxidation of ethanol

Amyloids are highly ordered nanofibrils and their tensile strength is similar to that of steel, which makes them resistant to extreme pH and temperature. Based on this rationale, we demonstrate a facile synthesis of palladium, copper, platinum, gold and silver nanocomposites using α-Synuclein (α-Syn) fibrils as a template. We showed that an α-Syn-fibril-palladium nanoparticles (α-Syn-PdNPs) composite can be used as a heterogeneous catalyst in C-H bond activation and the electrooxidation of ethanol. The study demonstrated α-Syn-PdNPs to be a superior heterogeneous catalyst for the synthesis of pharmaceutically valuable benzofuran, naphthofuran, coumarin and N-arylindole via C-H activation. Further, the electrooxidation of ethanol using α-Syn-PdNPs displayed an electrochemically active surface area of 160.6 m2 g-1, which is much higher than the previously reported values for supported Pd nanocomposites.

A naphtho furan synthetic method of compound

The invention provides synthetic methods of naphthopyran compounds. According to the methods, 2-naphthol compounds and aryl terminal alkyne compounds are taken as the raw materials, 2,3-dichloro-5,6-dicyano-1,4-benzoquinone is taken as an oxidizing agent

BF3-catalyzed oxidative tandem annulation-aromatization of naphthols with terminal aryl alkenes

A metal-free oxidative arene/alkene annulation-aromatization has been realized, which enables efficient synthesis of 2-arylnaphtho[2,1-b]furans from readily available terminal aryl alkenes and 2-naphthols. Mechanistic study suggests that this reaction proceeds via free-radical initiated tandem cyclization, dehydrogenative rearomatization and aromatization.

A Pincer Ruthenium Complex for Regioselective C-H Silylation of Heteroarenes

A pincer Ru(II) catalyst for the highly efficient undirected silylation of O- and S-heteroarenes with (TMSO)2MeSiH and Et3SiH is described, producing heteroarylsilanes with exclusive C2-regioselectivity, good functional-group tolerance, and high turnover numbers (up to 1960). The synthetic utility of the silylated products is demonstrated by Pd-catalyzed Hiyama-Denmark cross-coupling under mild conditions. One-pot, two-step silylation and coupling procedures have been also developed.