56344-91-3Relevant academic research and scientific papers
Preparation of Quinazolinoquinazolinones via a Cascade Approach
Ramanathan, Mani,Liu, Shiuh-Tzung
, p. 14138 - 14145 (2018/11/23)
A one-pot synthesis of quinazolino[3,4-a]quinazolin-13-ones was realized from the direct reaction of o-(methoxycarbonyl)benzenediazonium salts, nitriles, and 2-cyanoanilines in moderate to good yields. This method utilizes the in situ generation of reactive N-arylnitrilium ion, which undergoes further amination/tandem cyclization/amidation to deliver the desired polycyclic scaffolds with consecutive formation of four N-C bonds. Flexibility in substitution patterns, mild reaction conditions, and operational simplicity are the salient features of this methodology.
Polycyclic N-heterocyclic compounds. Part 601): Reactions of 3-(2-cyanophenyl)quinazolin-4(3H)-ones with primary amines
Okuda, Kensuke,Tagata, Tsuyoshi,Kashino, Setsuo,Hirota, Takashi,Sasaki, Kenji
experimental part, p. 1296 - 1299 (2010/05/02)
The reaction of 3-(2-cyanophenyl)quinazolin-4(3H)-one with various primary alkylamines gave 3-alkylquinazolin-4(3H)-ones via an addition of the nucleophile, ring opening, and ring closure (ANRORC) mechanism. This type of reaction required hydroxy group fu
Derivatives of 4(3H)-quinazolone, pharmaceutical compositions thereof and methods of use
-
, (2008/06/13)
A derivative of 4(3H)-quinazolone, its method of preparation, and pharmaceutical compositions are described. In particular, 2-methyl-3-(o-cyanophenyl)-4(3H)-quinazolone and its acid addition salts are described. This compound may be prepared by the reaction of N-acetylanthranilic acid with anthranilonitrile in the presence of a dehydrating agent. The quinazolone and its salts possess pharmacological activity.
