56346-02-2

Upstream product

• 33350-17-3 2-hydroxy-3,3-dimethylbutyronitrile 
• 93-58-3 benzoic acid methyl ester 
• 630-19-3 pivalaldehyde 
• 88522-73-0 trimethylacetaldehyde cyanohydrin trimethylsilyl ether 
• 63935-93-3 benzoyltriethylsilane 
• 82027-27-8 3,3-Dimethyl-1-phenyl-1-trimethylsilanyloxy-butan-2-one 
• 100-52-7 benzaldehyde 
• 25438-37-3 phenyl(trimethylsiloxy)acetonitrile 
• 82027-26-7 {2,2-Dimethyl-1-[1-phenyl-meth-(Z)-ylidene]-propoxy}-trimethyl-silane 
• 6721-67-1 tert-butyl benzyl ketone 
• 31675-43-1 diethyl 1-phenyl-1-(trimethylsiloxy)methanephosphonate 
• 6050-53-9 1-hydroxy-3,3-dimethyl-1-phenyl-butan-2-one 
• 56346-01-1 α-(trimethylsiloxy)-1-neopentyl phenyl ketone 
• 5425-44-5 2-Phenyl-[1,3]dithiane 

Downstream Products

• 7332-96-9 1-phenyl-3,3-dimethyl-1,2-butanedione 
• 630-19-3 pivalaldehyde 

Relevant academic research and scientific papers

The Direct Conversion of α-Hydroxyketones to Alkynes

Alkynes are highly important functional groups in organic chemistry, both as part of target structures and as versatile synthetic intermediates. In this study, a protocol for the direct conversion of α-hydroxyketones to alkynes is reported. In combination with the variety of synthetic methods that generate the required starting materials by forming the central C-C bond, it enables a highly versatile fragment coupling approach toward alkynes. A broad scope for this novel transformation is shown alongside mechanistic insights. Furthermore, the utility of our protocol is demonstrated through its application in concert with varied α-hydroxyketone syntheses, giving access to a broad spectrum of alkynes.

Mechanism and scope of the cyanide-catalyzed cross silyl benzoin reaction

In this work, cross silyl benzoin addition reactions between acylsilanes (1) and aldehydes (2) catalyzed by metal cyanides are described. Unsymmetrical aryl-, heteroaryl-, and alkyl-substituted benzoin adducts can be generated in moderate to excellent yie

Electrosynthesis of 1,2 diketones by reduction of aromatic esters at freshly metal coated electrodes: A novel coupling reaction

The one-step electrosynthesis of 1,2 aryldiketones has been achieved by constant current electrolysis of aromatic esters in an undivided cell fitted with a cadmium coated cathode and a sacrificial magnesium anode. Evidence is given for a role of Mg2+ ions in the pathway of the reaction.

Trifluoromethanesulfonic (Triflic) Acid Catalyzed Transformations of α-Hydroxy Carbonyl Compounds

Triflic acid catalyzed reaction of 2-hydroxy-2-adamantanecarboxylic acid results via ionizative decarbonylation in the formation of adamantanone.Under carbon monoxide pressure pinacol-type rearrangement gives 4,5-homoadamantanedione.Reactions of a series of α-hydroxy ketones result in fragmentation, deprotonation, and cyclization, respectively.The reactions and their suggested mechanism are discussed.

ADDITION OF GRIGNARD REAGENTS TO O-TRIMETHYLSILYLATED CYANOHYDRINS: SYNTHESIS OF ACYLOINS

Grignard reagents have been found to react readily with O-trimethylsilylated cyanohydrins to afford, after acid hydrolysis of intermediates, good yields of acyloins.

α-HETEROSUBSTITUTED PHOSPHONATE CARBANIONS IX : DIETHYL 1-PHENYL-1-TRIMETHYLSILOXYMETHANE PHOSPHONATE AS AN ACYL ANION EQUIVALENT; A NOVEL METHOD FOR THE PREPARATION OF α-HYDROXYKETONES.

Diethyl 1-phenyl-1-trimethylsiloxymethane phosphonate carbanion was found to react as an effective acyl anion equivalent in the preparation of α-hydroxy ketones from aliphatic and aromatic aldehydes and ketones.A 1,4-oxygen-oxygen silicon migration was also observed.