6721-67-1

Basic information

• Product Name: 3,3-DIMETHYL-1-PHENYL-BUTAN-2-ONE
• Synonyms: 3,3-DIMETHYL-1-PHENYL-BUTAN-2-ONE
• CAS NO: 6721-67-1
• Molecular Formula: C₁₂H₁₆O
• Molecular Weight: 176.25484
• Mol File: 6721-67-1.mol
• Article Data: 40

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3,3-DIMETHYL-1-PHENYL-BUTAN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3-DIMETHYL-1-PHENYL-BUTAN-2-ONE(6721-67-1)
• EPA Substance Registry System: 3,3-DIMETHYL-1-PHENYL-BUTAN-2-ONE(6721-67-1)

Safety Data

• Hazardous Substances Data: 6721-67-1(Hazardous Substances Data)

Usage

General Description

3,3-DIMETHYL-1-PHENYL-BUTAN-2-ONE, also known as 2,2-Dimethyl-1-phenylpropan-1-one or P2P, is a chemical compound with a molecular formula of C12H16O. It is a colorless liquid with a sweet, floral odor that is commonly used in the synthesis of amphetamine and methamphetamine. P2P is a precursor to amphetamines and acts as an intermediate in the illegal production of these drugs. Due to its role in the illegal drug trade, P2P is a controlled substance in many countries and is closely monitored and regulated by law enforcement agencies.

Upstream product

• 677-22-5 tert-butylmagnesium chloride 
• 103-80-0 phenylacetyl chloride 
• 598-98-1 Methyl pivalate 
• 1538-75-6 2,2-dimethylpropanoic anhydride 
• 108-88-3 toluene 
• 630-19-3 pivalaldehyde 
• 5425-44-5 2-Phenyl-[1,3]dithiane 
• 507-19-7 t-butyl bromide 
• 140-29-4 phenylacetonitrile 
• 75-97-8 3,3-dimethyl-butan-2-one 
• 108-86-1 bromobenzene 
• 444729-05-9 C₁₂H₁₆O 
• 591-50-4 iodobenzene 
• 18698-96-9 o-iodophenylacetic acid 

Downstream Products

• 3846-66-0 (E)-1-tert-butyl-2-phenylethene 
• 56277-62-4 (1-bromo-3,3-dimethylbutyl)benzene 
• 43121-47-7 Bromo-1 dimethyl-3,3 phenyl-1 butanone-2 
• 94743-20-1 1-(3,3-Dimethyl-2-oxo-1-phenyl-butyl)-3-(2,3-dimethyl-phenyl)-1H-quinazoline-2,4-dione 
• 94743-47-2 1-((E)-3,3-Dimethyl-2-phenethyloxy-1-phenyl-but-1-enyl)-1H-imidazole 
• 94743-36-9 4,5-Bis-(4-bromo-phenyl)-2,2-dimethyl-hexan-3-one 
• 94743-35-8 1,2-Bis-(4-bromo-phenyl)-4,4-dimethyl-pentan-3-one 
• 94743-34-7 4-(4-Bromo-phenyl)-2,2-dimethyl-5-phenyl-hexan-3-one 
• 94743-33-6 4-(4-Bromo-phenyl)-2,2-dimethyl-6-phenyl-hexan-3-one 
• 94743-46-1 1-((E)-2-Ethoxy-3,3-dimethyl-1-phenyl-but-1-enyl)-1H-imidazole 
• 94743-32-5 2-(4-Bromo-phenyl)-4,4-dimethyl-1-phenyl-pentan-3-one 
• 95546-24-0 1-Imidazol-1-yl-4,4-dimethyl-2-phenyl-pentan-3-one 
• 94743-45-0 1-Imidazol-1-yl-3,3-dimethyl-1-phenyl-butan-2-one 
• 94743-31-4 4-(4-Bromo-phenyl)-2,2-dimethyl-hexan-3-one 

Relevant articles and documents

Asymmetric Enamide–Imine Tautomerism in the Kinetic Resolution of Tertiary Alcohols

An efficient protocol for kinetic resolution of tertiary alcohols has been developed through an unprecedented asymmetric enamide-imine tautomerism process enabled by chiral phosphoric acid catalysis. A broad range of racemic 2-arylsulfonamido tertiary allyl alcohols could be kinetically resolved with excellent kinetic resolution performances (with s-factor up to >200). This method is particularly effective for a series of 1,1-dialkyl substituted allyl alcohols, which produced chiral tertiary alcohols that would be difficult to access via other asymmetric methods. Facile and versatile transformations of the chiral α-hydroxy imine and enamide products, especially the efficient stereodivergent synthesis of all four stereoisomers of β-amino tertiary alcohols using one enantiomer of the catalyst, demonstrated the value of this kinetic resolution method.

Ketone Synthesis from Benzyldiboronates and Esters: Leveraging α-Boryl Carbanions for Carbon-Carbon Bond Formation

An alkoxide-promoted method for the synthesis of ketones from readily available esters and benzyldiboronates is described. The synthetic method is compatible with a host of sterically differentiated alkyl groups, alkenes, acidic protons α to carbonyl groups, tertiary amides, and aryl rings having common organic functional groups. With esters bearing α-stereocenters, high enantiomeric excess was maintained during ketone formation, establishing minimal competing racemization by deprotonation. Monitoring the reaction between benzyldiboronate and LiOtBu in THF at 23 °C allowed for the identification of products arising from deborylation to form an α-boryl carbanion, deprotonation, and alkoxide addition to form an "-ate" complex. Addition of 4-trifluoromethylbenzoate to this mixture established the α-boryl carbanion as the intermediate responsible for C-C bond formation and ultimately ketone synthesis. Elucidation of the role of this intermediate leveraged additional bond-forming chemistry and enabled the one-pot synthesis of ketones with α-halogen atoms and quaternary centers with four-different carbon substituents.

Super electron donor-mediated reductive desulfurization reactions

The desulfurization of thioacetals and thioethers by a pyridine-derived electron donor is described. This methodology provides efficient access to the reduced products in high yields and does not require the use of transition-metals, elemental alkali-metals, or hydrogen atom donors.