564-10-3Relevant academic research and scientific papers
Preparation method of 1,1,3,3,3-pentafluoropropylene
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Paragraph 0033-0038, (2019/04/27)
The invention discloses a preparation method of 1,1,3,3,3-pentafluoropropylene. The preparation method comprises the following steps: (1) carrying out a reaction on halgen-containing inorganic salt and sevofluoroisobutenyl methyl ether in a first aprotic solvent, adding water into the solution to stir, cool and filter after the reaction, and rectifying the filtrate to obtain hexafluoroisobutyric acid; and (2) carrying out a reaction on the hexafluoroisobutyric acid obtained in the step (1) and a hydrogen ion capturing agent, collecting a generated gas phase product and cooling the product to obtain the 1,1,3,3,3-pentafluoropropylene product. The preparation method has the advantages of being simple in process, environment-friendly, low in cost and green and environment-friendly.
Preparation method of 1, 1, 1, 3, 3, 3-hexafluoropropane
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Paragraph 0035-0039, (2019/05/08)
The invention discloses a preparation method of 1, 1, 1, 3, 3, 3-hexafluoropropane. The method includes: (1) reacting a halogenated inorganic salt with heptafluoroisobutenyl methyl ether in an aproticsolvent, then adding water and performing stirring, conducting cooling and filtering, and rectifying the filtrate to obtain hexafluoroisobutyric acid; and (2) heating the hexafluoroisobutyric acid obtained in step (1), collecting the generated gaseous product and performing cooling to obtain the 1, 1, 1, 3, 3, 3-hexafluoropropane product. The method provided by the invention has the advantages ofsimple process, environmental friendliness, low cost, green and environmental protection.
Synthesis of 3,3,3-trifluoroethyl isocyanate, carbamate and ureas. Anticancer activity evaluation of N-(3,3,3-trifluoroethyl)-N′-substituted ureas
Luzina, Elena L.,Popov, Anatoliy V.
, p. 82 - 88 (2015/06/25)
A new method is described for producing 3,3,3-trifluoroethyl isocyanate from perfluoroisobutene (PFIB). Isocyanate was used for synthesis of carbamates and ureas. A series of trifluoroethyl-substituted ureas has been tested in the National Cancer Institute (NCI, Bethesda, USA) by the NCI-60 DTP Human Tumor Cell Line Screening Program at a single high dose (10-5 M). The moderate anticancer activity was shown against some types of cancer on the individual human cell lines for leukemia, non-small cell lung cancer and renal cancer.
Synthesis of 1-aroyl(1-arylsulfonyl)-4-bis(trifluoromethyl)alkyl semicarbazides as potential physiologically active compounds
Luzina, Elena L.,Popov, Anatoliy V.
, p. 41 - 48 (2013/04/10)
1,1-Bis(trifluoromethyl)alkyl isocyanates obtained from perfluoroisobutene (PFIB) react with aroyl(arylsulfonyl)hydrazines. Twenty eight prospective biologically active polyfluorinated 1,4-substituted semicarbazides were synthesized. The structure of each
Chemoselective halogenation of 2-hydroperfluoroalkyl aldehydes
Wiebe, Donald A.,Burton, Donald J.
experimental part, p. 4 - 11 (2012/07/13)
2-Hydroaldehydes, RfCH(R)CHO, where Rf = CF 3, C2F5, n-C3F7 and R = CF3, C2F5, n-C3F7, Ph, H, were prepared via acid hydrolysis of the corresponding vinyl ethers, R fC(R) = CHOCH3, which can be readily prepared by reaction of Ph3P+C?HOCH3 with the corresponding ketone. The 2-hydroaldehydes can be chemoselectively converted to the acyl halide, RfCH(R)C(O)X (X = Cl, Br), via free-radical halogenation. The perfluoroalkyl group deactivates the 2-position toward radical abstraction of the 2-hydrogen, and halogenation occurs exclusively at the formyl hydrogen. However, halogenations of the 2-hydroaldehydes in glacial acetic acid chemoselectively gives the 2-haloaldehydes, RfCX(R)CHO, X = Cl, Br. Hydrolysis of the 2-hydroperfluoroacyl halides provides a useful route to 2-hydroperfluoroalkyl branched carboxylic acids, useful ketene precursors. This route avoids the use of toxic fluoroolefins, such as perfluoroisobutylene.
Synthesis and anticancer activity of N-bis(trifluoromethyl)alkyl-N′-thiazolyl and N-bis(trifluoromethyl)alkyl-N′-benzothiazolyl ureas
Luzina, Elena L.,Popov, Anatoliy V.
experimental part, p. 4944 - 4953 (2010/02/27)
A number of N-bis(trifluoromethyl)alkyl-N′-thiazolyl and -benzothiazolyl ureas have been synthesized and evaluated for their in vitro antiproliferative activities against the human cancer cell lines at the National Cancer Institute (NCI, USA). The activity was shown for compounds 8a,c and 9a-c. The most sensitive cell lines relative to the tested compounds are: 8c PC-3 (prostate cancer, log GI50 -7.10), 9c SNB-75 (CNS cancer, log GI50 -5.84), 9b UO-31 (renal cancer, log GI50 -5.66), and SR (leukemia, log GI50 -5.44) human cancer cells.
Novel reactions of perfluoro-2-(trifluoromethyl)-propene
Munavalli, S.,Lewis, E. O.,Muller, A. J.,Rossman, D. I.,Rohrbaugh, D. K.,Ferguson, C. P.
, p. 253 - 264 (2007/10/02)
Unlike its hydrocarbon counterpart, perfluoro-2-(trifluoromethyl)propene is a highly reactive compound.It participates in both heterolytic and homolytic reactions.It readily reacts with nucleophiles and sluggishly with electrophiles.It reacts as well with common organic solvents, such as dimethylformamide, ethanol and others.In this communication we describe its reactions with trifluoromethylthiocopper, sulfur trioxide and tributyltin cyanide, the mechanism of formation of the various products and their mass spectral data.
Substituted aryloxy-3,3,3-trifluoro-2-propionic acids, esters and salts thereof
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, (2008/06/13)
Derivatives of 2-hydroxy-3,3,3-trifluoro-2-(alkyl or trifluoromethyl)propionic acid bearing a phenyl or naphthyl group linked to the 2-hydroxy group either directly or via an intermediate methylene group. The compounds reduce the concentrations of cholesterol, total esterified fatty acids or fibrinogen in the blood plasma of test animals and some compounds show anti-arthritic properties.
