56406-26-9

Usage

Chemical Properties

White solid

InChI:InChI=1/C11H8N2O3/c14-10-8(11(15)16)6-12-9(13-10)7-4-2-1-3-5-7/h1-6H,(H,15,16)(H,12,13,14)

Upstream product

• 49597-05-9 propene-1,1,3,3-tetracarboxylic acid tetraethyl ester 
• 613-92-3 N-hydroxybenzenecarboximidamide 
• 1670-14-0 benzamidine monohydrochloride 
• 55613-22-4 4-hydroxy-2-phenyl-5-pyrimidinecarboxylic acid ethyl ester 
• 74222-83-6 benzamidine hydrochloride hydrate 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 24755-82-6 ethyl 4-chloro-2-phenylpyrimidine-5-carboxylate 
• 97693-08-8 2-phenyl-5H-pyrido<1,2-a>pyrimido<5,4-e>pyrimidin-5-one 

Downstream Products

• 66206-81-3 4-chloro-2-phenylpyrimidine-5-carbonyl chloride 
• 139438-55-4 6-phenyl-1H-pyrazolo<3,4-d>pyrimidin-3(2H)-one 
• 139438-56-5 6-phenyl-1H-pyrazolo<3,4-d>pyrimidin-3(2H)-thione 
• 139438-48-5 3-chloro-6-phenyl-1H-pyrazolo<3,4-d>pyrimidine 
• 139438-51-0 3-methylthio-6-phenyl-1H-pyrazolo<3,4-d>pyrimidine 
• 139438-49-6 3-dimethylamino-6-phenyl-1H-pyrazolo<3,4-d>pyrimidine 
• 139438-46-3 (6-phenyl-1H-pyrazolo<3,4-d>pyrimidin-3-yl)hydrazine 
• 139438-58-7 7-Methyl-2-phenyl-thiazolo[3',2':1,5]pyrazolo[3,4-d]pyrimidine 
• 139438-47-4 3-azido-6-phenyl-1H-pyrazolo<3,4-d>pyrimidine 
• 139438-64-5 2-phenyl-9H-tetrazolo<1',5':1,5>pyrazolo<3,4-d>pyrimidine 
• 139438-62-3 2-phenyl-9H-<1,2,4>triazolo<3',4':3,2>pyrazolo<3,4-d>pyrimidine-7(6H)-thione 
• 139438-52-1 <(6-phenyl-1H-pyrazolo<3,4-d>pyrimidin-3-yl)thio>propanone 
• 139438-50-9 3-(p-chlorobenzyl)amino-6-phenyl-1H-pyrazolo<3,4-d>pyrimidine 
• 139438-60-1 7-(p-chlorophenyl)-2-phenyl-9H-<1,2,4>triazolo<3',4':3,2>pyrazolo<3,4-d>pyrimidine 

Relevant academic research and scientific papers

Tricyclic Heteroaromatic Systems Containing a Bridgehead Nitrogen Atom. Part 3. Triazolopyrazolopyrimidines, Tetrazolopyrazolopyrimidines and Pyrimidopyrazolotriazines

6-Phenyl-1H-pyrazolopyrimidin-3(2H)-one 16 has been prepared and converted into its 3-chloro 6, 3-thioxo 17 and 3-methylthio derivatives 9.Each of these could be converted into the 3-hydrazino derivative 3, cyclisation of which with carbon disulfide or triethyl orthoformate generated the fused 1,2,4-triazoles 23 and 20, respectively.Alternatively, the hydrazino derivative 3 gave a substituted hydrazide 26 or thiosemicarbazide 25, from which the 1,2,4-triazoles 21 and 22 respectively were obtained.The equilibrium between 3-azido-6-phenyl-1H-pyrazolopyrimidine 5 and 2-phenyl-9H-tetrazolopyrazolopyrimidine 27 was studied. 3-Diazo-4-methyl-6-phenyl-1H-pyrazolopyrimidine 29 was prepared by diazotisation of the corresponding amine 1 and converted into the 3-azido compound 4, which could not be cyclised to form a tetrazole.Finally, the diazo compound 29 readily formed the pyrimidopyrazolotriazine derivatives 32 and 33, when treated with pentane-2,4-dione and ethyl acetoacetate respectively.

Reactions of Ethyl 4-Chloro-5-pyrimidinecarboxylates with 2-Aminopyridine. Synthesis of 5H-Pyridopyrimidopyrimidin-5-ones and 5H-Pyridopyrimidopyrimidin-5-ones and Rearrangement of the Former to the Latter

5H-Pyridopyrimidopyrimidin-5-ones IVa,b and 5H-pyridopyrimidopyrimidin-5-ones Va,b were synthesized from ethyl 4-chloro-5-pyrimidinecarboxylate and 2-aminopyridine.The former compounds were obtained directly upon heating the reactants in ethanol, and the latter were prepared by the fusion of ethyl 4-(2-pyridylamino)-5-pyrimidinecarboxylates obtained as minor products from the above reaction.The angular fused cyclic compounds IVa,b were rearranged to the linear tricycles Vb-f upon heating with amines.

Antiallergy agents. I. 1,6-dihydro-6-oxo-2-phenylpyrimidine-5-carboxylic acids and esters

The synthesis of some 1,6-dihydro-6-oxo-2-phenylpyrimidine-5-carboxylic acids and esters with potent oral and intravenous antiallergic activity against passive cutaneous anaphylaxis in the rat is described. Requirements for high activity include a free NH group in the pyrimidinone nucleus and a small to medium size ortho alkoxy or alkenyloxy group on the phenyl ring. It is suggested that in the case of the highly active compounds hydrogen bonding occurs between a nitrogen of the pyrimidine ring and the ethereal oxygen. The nature of this bonding and its possible contribution to an optimum configuration for the molecules is discussed.

Bis(4-[4'-hydroxy-5'-carboxy-2'-pyrimidinyl]phenoxy)alkanes

5-Carboxypyrimidine derivatives and their pharmaceutically acceptable basic salts, and their use as antiallergy agents.