56414-03-0Relevant academic research and scientific papers
Structural characterisation of 2,3-disubstituted pyrazines: NMR and X-ray crystallography
Farrán, M. ángeles,Claramunt, Rosa M.,López, Concepción,Pinilla, Elena,Torres, M. Rosario,Elguero, José
, p. 67 - 75 (2007/10/03)
2-Formyl-3-aminopyrazine (1), 2-acetyl-3-aminopyrazine (2) and 2-benzoyl-3-aminopyrazine (3) have been studied by multinuclear magnetic resonance spectroscopy in solution and in solid state. Amino-imine tautomerism in such derivatives has been discussed on the basis of the calculated stabilities of the different tautomers by the hybrid B3LYP/6-31G** method. The crystalline structure of compound 3 has been solved, it belongs to the monoclinic P21/n space group, and shows supramolecular architectures involving N-H?O and N-H?N-pyrazine intermolecular hydrogen bonds.
A New Route to 2,3-Disubstituted Pyrazines; Regioselective Metalation of Chloropyrazine
Turck, A.,Mojovic, L.,Queguiner, G.
, p. 881 - 884 (2007/10/02)
Chloropyrazine is regioselectively metalated by lithium amides in tetrahydrofuran to give 3-chloro-2-lithiopyrazine.The reaction of this lithio derivative with electrophiles can either be performed in situ (with the electrophile, e.g., chlorotrimethylsila
