13739-49-6Relevant academic research and scientific papers
FERROPORTIN INHIBITORS AND METHODS OF USE
-
Paragraph 0686; 0687, (2020/07/07)
The subject matter described herein is directed to Ferroportin inhibitor compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, particularly iron overload states, such as thalassemia, sickle cell disease and hemochromatosis.
Highly efficient and eco-friendly protocol to functionalized imidazoles via ring-opening of α-nitro epoxides
Guo, Xiao,Shao, Jiaan,Liu, Huan,Chen, Binhui,Chen, Wenteng,Yu, Yongping
, p. 51559 - 51562 (2015/06/25)
A simple and direct synthesis of functionalized imidazoles from α-nitro-epoxides and amidines was developed. This reaction could proceed smoothly in a highly efficient and eco-friendly manner in moderate to excellent yields. A plausible mechanism has also
Nano indium oxide catalyzed tandem cyclization of amidine with nitroolefin
Mitra, Shubhanjan,Bagdi, Avik Kumar,Majee, Adinath,Hajra, Alakananda
supporting information, p. 4982 - 4985 (2013/08/28)
A tandem cyclization of amidine with nitroolefin has been described using nano In2O3 as an efficient catalyst. The reaction is effective for the preparation of 4,5-unsymmetrically substituted 1-H imidazole in moderate to good yields. The catalyst was successfully reused for four consecutive cycles with similar catalytic activities.
Hypervalent iodine in synthesis 81: A one-pot procedure for the synthesis of 1H-imidazole derivatives by cyclocondensation of ketones with [Hydroxy(tosyloxy)iodo]benzene and amidines
Zhang,Chen
, p. 2075 - 2077 (2007/10/03)
Tosyloxylation of ketones with [hydroxy(tosyloxy)iodo]benzene (HTIB), followed by treatment with amidines provides a one-pot procedure for the synthesis of 1H-imidazole derivatives with good yields.
