5652-58-4

Upstream product

• 75-30-9 2-iodo-propane 
• 85-44-9 phthalic anhydride 
• 498-21-5 2-methylbutanedioic acid 
• 17190-77-1 2,2-dimethyl-indan-1,3-dione 
• 6962-79-4 3-Hydroxy-3-isopropyl-phthalid 
• 4767-54-8 3-(propan-2-ylidene)isobenzofuran-1(3H)-one 
• 920-39-8 isopropylmagnesium bromide 
• 75-26-3 isopropyl bromide 

Downstream Products

• 99291-16-4 1-(2-hydroxymethylphenyl)-2-methylpropan-1-ol 
• 6962-79-4 3-Hydroxy-3-isopropyl-phthalid 
• 1580457-34-6 2-(3-methylbut-1-en-2-yl)benzoic acid 
• 99291-14-2 α-(2-propyl)-α,α'-dibromoxylene 
• 32025-38-0 methyl 2-isobutyrylbenzoate 

Relevant academic research and scientific papers

Ruthenium-Catalyzed Enantioselective Hydrogenation/Lactonization of 2-Acylarylcarboxylates: Direct Access to Chiral 3-Substituted Phthalides

Highly enantioselective tandem hydrogenation/lactonization of various 2-acylarylcarboxylates including 2-aroylarylcarboxylates were realized by using [RuCl(benzene)(S)-SunPhos]Cl as the catalyst under mild reaction conditions. Excellent enantioselectivities (up to 99.6 % ee) and activities (S/C=1000) were obtained. This convenient and practical method enables a direct access to a series of highly optically pure 3-substituted phthalides that are very important molecules as valuable pharmacological compounds and diversified synthons for medicinal chemistry. Moreover, a gram-scale reaction was performed to further demonstrate the practicality of this approach.

Carboxy-directed asymmetric hydrogenation of α-alkyl-α-aryl terminal olefins: Highly enantioselective and chemoselective access to a chiral benzylmethyl center

A carboxy-directed asymmetric hydrogenation of α-alkyl-α-aryl terminal olefins was developed by using a chiral spiro iridium catalyst, providing a highly efficient approach to the compounds with a chiral benzylmethyl center. The carboxy-directed hydrogenation prohibited the isomerization of the terminal olefins, and realized the chemoselective hydrogenation of various dienes. The concise enantioselective syntheses of (S)-curcudiol and (S)-curcumene were achieved by using this catalytic asymmetric hydrogenation as a key step.

Ring-chain tautomerism. Part 10 +. The reaction of oxocarboxylic acids with diazodiphenylmethane

The rate coefficients for the esterification of a series of oxocarboxylic acids with diazodiphenylmethane have been determined in ethanol or 2-methoxyethanol at 30.0°C. These and the rates of reaction with model compounds have been used to estimate the equilibrium constants for ring-chain tautomerism for the oxocarboxylic acids.