565452-82-6

Upstream product

• 500870-86-0 4-(aminosulfonyl)-N-[2-(4-methoxybenzoyl)phenyl]benzamide 
• 6311-23-5 2-(toluene-4-sulfonylamino)-benzoic acid 
• 36192-61-7 2-amino-4'-methoxybenzophenone 
• 42840-02-8 2-(Toluene-4-sulfonylamino)-benzoyl chloride 
• 118-92-3 anthranilic acid 
• 51594-97-9 4-sulfamoylbenzoyl chloride 
• 75127-50-3 N-[2-(4-methoxybenzoyl)phenyl]-4-(methyl)benzenesulfonamide 
• 500870-96-2 2-[4-(aminosulfonyl)phenyl]-3-(4-methoxyphenyl)-1H-indole 

Relevant academic research and scientific papers

Sulfonyl-containing 2,3-diarylindole compounds, methods for making same, and methods of use thereof

The present invention relates to sulfonyl-containing 2,3-diarylindole, especially to new compounds of general Formula, to a preparation method for their preparation, to pharmaceutical compositions containing said compound, and to the medical use thereof in the treatment of diseases relating to the inhibition of cyclooxygenase-2 (COX-2).

Synthesis and biological evaluation of substituted 2-sulfonyl-phenyl-3-phenyl-indoles: A new series of selective COX-2 inhibitors

A new series of substituted 2-sulfonyphenyl-3-phenyl-indole derivatives were synthesized and evaluated for their ability to inhibit COX-2 and COX-1enzymes. Most of the compounds synthesized were found to be highly potent and selective inhibitors of COX-2. This work led to the discovery of 2-aminosulfonylphenyl-3-phenyl-indole 5a which possesses higher activity and selectivity for COX-2 than Celecoxib both in vitro and in vivo.