56570-63-9

Upstream product

• 52776-36-0 E-1-phenyl-3-chloro-2-buten-1-one 
• 124-40-3 dimethyl amine 
• 18871-66-4 N,N-dimethylacetamide dimethyl acetal 
• 98-86-2 acetophenone 

Downstream Products

• 39159-65-4 1-benzoyl-2-(N-phenylamino)-1-propene 
• 343336-88-9 3-Methylamino-1-phenyl-cis-buten-⁽²⁾-on-⁽¹⁾ 
• 70008-83-2 (E)-3-Benzylamino-1-phenyl-but-2-en-1-one 
• 80012-15-3 1-benzoyl-2-amino-1-propene 
• 114003-61-1 2-methyl-3-benzoyl-5-hydroxynaphtho<1,2-b>furan 
• 59382-08-0 2-methyl-3-benzoyl-4,9-dihydronaphtho<2,3-b>furan-4,9-dione 
• 221206-31-1 2-methyl-3-benzoyl-5-methoxynaphtho<1,2-b>furan 
• 221206-27-5 2-methyl-3-benzoyl-4,5-dihydronaphtho<1,2-b>furan-4,5-dione 
• 221206-37-7 2-dimethylamino-3-(3-benzoyl-5-methoxynaphtho<1,2-b>furan-2-yl)-5-hydroxybenzofuran 
• 6123-67-7 (5-methyl-1-phenyl-1H-pyrazol-4-yl)-phenyl-methanone 
• 93251-37-7 (3-methyl-1-phenyl-1H-pyrazol-4-yl)(phenyl)methanone 
• 57626-33-2 2-bromo-1-phenyl-1,3-butanedione 
• 75237-40-0 4-benzoyl-5-methyl-1H-imidazol-2(3H)-one 

Relevant academic research and scientific papers

Reactions of enaminones and related compounds with N,N-dimethylacetamide dimethyl acetal. A simple one-pot metal-free synthesis of polysubstituted benzene derivatives

Herein a simple one-pot metal-free synthesis of alkyl-, aryl-, heteroaryl- and alkoxycarbonyl substituted 1,3-bis(dimethylamino)benzene derivatives is described. The products were prepared from the corresponding methyl ketones or compounds with an α-methylene group in regard to the carbonyl group, using N,N-dimethylacetamide dimethyl acetal (DMADMA) as the reagent.

A simple synthesis of 4-aroyl-5-methyl-1H-imidazol-2(3H)-one derivatives (Enoxymone analogues) from aryl methyl ketones via enaminones

Aryl methyl ketones 1a-e gave with N,N-dimethylacetamide dimethylacetal (DMADMA) (E)-1- aryl-3-(dimethylamino)-but-2-en-1-ones 2a-e. Substitution of the N,N-(dimethylamino) group in the reaction with ammonium acetate afforded the corresponding (Z)-3-amino-1-aryl-but-2-en-1- ones 3a-e. In the reaction of 3a-e with diethyl azodicarboxylate intermediates 4a-e were formed, which were, in most cases without isolation, cyclized into ethyl (5-aroyl-4-methyl-2-oxo-2,3- dihydro-1H-imidazol-1-yl)carbamates 5a-e. Hydrolysis of the ester group, followed by the decarboxylation and deamination of intermediates 6a-c,e produced 4-aroyl-5-methyl-1Himidazol- 2(3H)-ones 7a-c,e.