56570-68-4Relevant academic research and scientific papers
Solvent-controlled two-step one-pot syntheses of α-X (X = Br or Cl) enamino ketones/esters and 3-(2,5-dioxopyrrolidin-1-yl)acrylate by using terminal carbonyl alkynes
Chen, Xiao Yun,Yuan, Shuxia,Chen, Yan,Sun, Chenyang,Tang, Yaonan,Chen, Guang,Zhu, Baocheng,Chen, Kaiwei,Zheng, Shaojun,Cheng, Xiaofang
supporting information, p. 7914 - 7919 (2021/09/28)
A new two-step one-pot aminobromination/chlorination of carbonyl alkynes has been achievedviaa Michael addition of aliphatic secondary amines and subsequent β-bromination/chlorination of the obtained enamines to afford various α-X (X = Br or Cl) enamino ketones/esters in moderate to good yields. A solvent-controllable protocol has been developed to produce versatile 3-(2,5-dioxopyrrolidin-1-yl)acrylates in moderate yields by using toluene as the solvent and chain alkyl propiolates as alkynyl substrates.
Synthetic Route to Enaminones via Metal-Free Four-Component Sequential Reactions of Aryl Olefins with CHCl3, Et3N, and TBHP
Zhang, Jiantao,Zhou, Peng,Yin, Aiguo,Zhang, Shuhua,Liu, Weibing
, p. 8980 - 8986 (2021/06/30)
An efficient and modular strategy was used to obtain enaminones with a wide range of functional groupsviaa four-component sequential reaction. This reaction proceeded under mild conditions without a catalyst in one pot. Furthermore, the products could be transformed into thiadiazoles.
