56652-39-2

Basic information

• Product Name: dimethyl 3-hydroxy-3-methylglutarate
• Synonyms: dimethyl 3-hydroxy-3-methylglutarate;3-Hydroxy-3-methylpentanedioic acid dimethyl ester;Einecs 260-314-0
• CAS NO: 56652-39-2
• Molecular Formula: C₈H₁₄O₅
• Molecular Weight: 190.19376
• EINECS: 260-314-0
• Mol File: 56652-39-2.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 274.6°Cat760mmHg
• Flash Point: 103.6°C
• Appearance: /
• Density: 1.151g/cm³
• Vapor Pressure: 0.000677mmHg at 25°C
• Refractive Index: 1.447
• PKA: 12.67±0.29(Predicted)
• CAS DataBase Reference: dimethyl 3-hydroxy-3-methylglutarate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl 3-hydroxy-3-methylglutarate(56652-39-2)
• EPA Substance Registry System: dimethyl 3-hydroxy-3-methylglutarate(56652-39-2)

Safety Data

• Hazardous Substances Data: 56652-39-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H14O5/c1-8(11,4-6(9)12-2)5-7(10)13-3/h11H,4-5H2,1-3H3

Upstream product

• 186581-53-3 diazomethane 
• 503-49-1 meglutol 
• 67-56-1 methanol 
• 124-41-4 sodium methylate 
• 117278-74-7 tangshenoside I 
• 2018-45-3 4-(β-hydroxyethyl)-4-methyl-1,3-dioxane 
• 114637-86-4 3,5-di-O-caffeoyl-4-O-(3-hydroxy-3-methyl)glutaroylquinic acid dimethyl ester 
• 114637-82-0 3,5-di-O-caffeoyl-4-O-(3-hydroxy-3-methyl)glutaroylquinic acid 
• 114653-47-3 tetramethylether of 3,5-di-O-caffeoyl-4-O-(3-hydroxy-3-methyl)glutaroylquinic acid dimethyl ester 
• 25201-40-5 1,1-diallylethanol 

Downstream Products

• 117970-27-1 dl-tert-butyl 2-tert-butoxycarbonyl-5-hydroxy-5-methyl-3-oxo-1-cyclohexene-1-acetate 
• 7564-64-9 3-methyl-1,3,5-pentanetriol 
• 300719-37-3 (R)-5-(tert-Butyldimethylsilyloxy)-3-methoxy-5-methylhex-2-en-1-one 

Relevant articles and documents

AMINOPYRAZOLONE DERIVATIVE

The present invention is intended to provide a compound or a pharmacologically acceptable salt thereof which has an excellent inhibitory action on the ATPase activity of a TIP48/TIP49 complex and as such, is useful for the treatment of tumors. [Solution] The present invention provides a compound having a structure represented by the general formula (I) or a pharmacologically acceptable salt thereof, and a pharmaceutical composition comprising the compound. In the formula, R1, R2, R3, R4, R5, R6, R7, and W are as defined in the present specification.

A gas-liquid chromatographic method for steric analysis of 2-hydroxy, 3-hydroxy, and 2,3-dihydroxy acids

A method was developed for assignment of the absolute configuration of oxylipin-derived 2-hydroxy acids, 3-hydroxy acids and 2,3-dihydroxy acids.The monohydroxy acids were converted into diastereomeric N-(propionoxyacyl)-L-phenylalanine-methyl ester (PAP) derivatives by coupling to the methyl ester of L-phenylalanine followed by propionylation, whereas 2,3-dihydroxy acids were derivatized by treatment with L-phenylalanine methyl ester followed by acetone and perchloric acid, to afford diastereomeric N-(2,3-isopropylidenedioxyacyl)-L-phenylalanine methyl ester (IAP) derivatives.The PAP and IAP derivatives were readily resolved by capillary gas-liquid chromatography.In addition, the method described allowed steric analysis of 3-hydroxy-3-methylheptanoic acid, a branched chain hydroxy acid derived from the prostaglandin analogue, misoprostol. - Keywords: Hydroxy acid; Phenylalanine; Steric analysis; Gas-liquid chromatography

OXIDATION OF 4-METHYL-4-(2-HYDROXYMETHYL)-1,3-DIOXANE TO 2-HYDROXY-2-METHYLGLUTARIC ACID

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