56652-39-2

Usage

InChI:InChI=1/C8H14O5/c1-8(11,4-6(9)12-2)5-7(10)13-3/h11H,4-5H2,1-3H3

Upstream product

• 186581-53-3 diazomethane 
• 503-49-1 meglutol 
• 67-56-1 methanol 
• 114653-47-3 tetramethylether of 3,5-di-O-caffeoyl-4-O-(3-hydroxy-3-methyl)glutaroylquinic acid dimethyl ester 
• 124-41-4 sodium methylate 
• 117278-74-7 tangshenoside I 
• 25201-40-5 1,1-diallylethanol 
• 2018-45-3 4-(β-hydroxyethyl)-4-methyl-1,3-dioxane 
• 114637-86-4 3,5-di-O-caffeoyl-4-O-(3-hydroxy-3-methyl)glutaroylquinic acid dimethyl ester 
• 114637-82-0 3,5-di-O-caffeoyl-4-O-(3-hydroxy-3-methyl)glutaroylquinic acid 

Downstream Products

• 117970-27-1 dl-tert-butyl 2-tert-butoxycarbonyl-5-hydroxy-5-methyl-3-oxo-1-cyclohexene-1-acetate 
• 7564-64-9 3-methyl-1,3,5-pentanetriol 
• 300719-37-3 (R)-5-(tert-Butyldimethylsilyloxy)-3-methoxy-5-methylhex-2-en-1-one 

Relevant academic research and scientific papers

AMINOPYRAZOLONE DERIVATIVE

The present invention is intended to provide a compound or a pharmacologically acceptable salt thereof which has an excellent inhibitory action on the ATPase activity of a TIP48/TIP49 complex and as such, is useful for the treatment of tumors. [Solution] The present invention provides a compound having a structure represented by the general formula (I) or a pharmacologically acceptable salt thereof, and a pharmaceutical composition comprising the compound. In the formula, R1, R2, R3, R4, R5, R6, R7, and W are as defined in the present specification.

Structure and absolute stereochemistry of syphonoside, a unique macrocyclic glycoterpenoid from marine organisms

(Figure Presented) The glycoterpenoid syphonoside (1) is the main secondary metabolite of both the marine mollusk Syphonota geographica and the sea-grass Halophila stipulacea, two Indo-Pacific species migrated to the Mediterranean Sea through the Suez Canal. The structure and the absolute stereochemistry of 1, which displays unique structural features, has been accomplished by using a combination of spectroscopic techniques, degradation reactions, and conformational analysis methods. Compound 1 was able to inhibit high density induced apoptosis in a number of human and murine carcinoma cell lines.

A gas-liquid chromatographic method for steric analysis of 2-hydroxy, 3-hydroxy, and 2,3-dihydroxy acids

A method was developed for assignment of the absolute configuration of oxylipin-derived 2-hydroxy acids, 3-hydroxy acids and 2,3-dihydroxy acids.The monohydroxy acids were converted into diastereomeric N-(propionoxyacyl)-L-phenylalanine-methyl ester (PAP) derivatives by coupling to the methyl ester of L-phenylalanine followed by propionylation, whereas 2,3-dihydroxy acids were derivatized by treatment with L-phenylalanine methyl ester followed by acetone and perchloric acid, to afford diastereomeric N-(2,3-isopropylidenedioxyacyl)-L-phenylalanine methyl ester (IAP) derivatives.The PAP and IAP derivatives were readily resolved by capillary gas-liquid chromatography.In addition, the method described allowed steric analysis of 3-hydroxy-3-methylheptanoic acid, a branched chain hydroxy acid derived from the prostaglandin analogue, misoprostol. - Keywords: Hydroxy acid; Phenylalanine; Steric analysis; Gas-liquid chromatography

Oxidation of putrescine and cadaverine derivatives by diamine oxidases

A range of putrescine and cadaverine derivatives has been synthesized and assayed as substrates for the diamine oxidases from pea seedlings and pig kidney. KM and Vmax data are reported, mainly for the pea enzyme. N-Alkylputrescines and C-alkylcadaverines are generally poorer substrates than the parent compounds with up to 4500-fold reduction in Vmax. There is significantly less variation in KM values, indicating that the binding site of the pea enzyme is relatively non-specific and that enzymic specificity lies at the catalytic stage. This suggests that poor substrates might act as convenient, short-lived inhibitors of diamine oxidases.

SYNTHETIC STUDIES ON NOGALAMYCIN CONGENERS ; TOTAL SYNTHESES OF (+)-NOGARENE, (+)-7-DEOXYNOGAROL, AND (+)-7-CON-O-METHYLNOGAROL

According to the retrosynthetic perspective, the title total syntheses were accomplished by employing the regioselective Diels-Alder reactions of the (+)-naphthoquinone (5), the CDEF-ring system of nogalamycin congeners, with various structural types of dienes (8, 16, and 26).The highly functionalized dienes (16 and 26) incorporating all the functionalities present in the A-rings of (+)-7-deoxynogarol (3) and (+)-7-con-O-methylnogarol (2), were prepared efficiently by way of the 1,4-cyclohexadiene and 2-cyclohexanone derivatives (6 and 21), respectively.Reaction mechanism of the key Diels-Alder reaction was also discussed in terms of its stereoselectivity.

TANGSHENOSIDES I AND II FROM CHUAN-DANGSHEN, THE ROOT OF CODONOPSIS TANGSHEN OLIV.

From the roots of Codonopsis tangshen (Chuan-dangshen) cultivated in Sichuan, China, two new phenylpropanoid glucosides named tangshenosides I and II were isolated together with syringin. the structures of both compounds including the absolute configurations were elucidated by physical and chemical procedures.KEYWORDS - codonopsis tangshen; Dangshen; Campanulaceae; Chinese folk medicine; tangshenoside I; tangshenoside II; syringin; phenylpropanoid glycoside;

Studies on a Synthesis of (RS)-Mevalonic Acid Lactone

Full details of a high yielding synthesis of mevalonic acid lactone (1) which is of particular value in the preparation of 3- and/or 3'-labelled compounds are described.The key step, conversion of 3-hydroxy-3-methylpentane-1,5-dioic acid (3) into 3-hydroxy-3-methylpentane-1,5-dioic anhydride (4) using acetic anhydride, has been fully investigated, and an additional method using acetyl chloride and triethylamine is described.