56680-34-3

Upstream product

• 91-56-5 indole-2,3-dione 
• 1439-43-6 1-(4-nitro-phenyl)-2-(triphenyl-λ⁵-phosphanylidene)-ethanone 
• 100-19-6 (4-nitrophenyl)ethanone 
• 70097-11-9 3-hydroxy-3-(2-oxo-2-(4-nitrophenyl)ethyl)indolin-2-one 
• 62-53-3 aniline 
• 42366-35-8 hydroxyimino-N-phenylacetamide 

Downstream Products

• 1421605-72-2 methyl (2-(4-(4-nitrobenzoyl)-1H-pyrrol-3-yl)phenyl)carbamate 
• 70097-13-1 2-(4-nitrophenyl)quinoline-4-carboxylic acid 
• 120422-14-2 (4-Nitro-phenyl)-(2-phenyl-9H-pyrido[2,3-b]indol-4-yl)-methanone 

Relevant academic research and scientific papers

Ultrasound-assisted synthesis of 3-(1-(2-(1H-indol-3-yl)ethyl)-2-aryl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-3-yl)indolin-2-ones by novel core-shell bio-based nanocatalyst anchoring sulfonated L-histidine on magnetized silica (SO3H-L-Hi

An efficient synthesis of 3-(1-(2-(1H-indol-3-yl)ethyl)-2-aryl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-3-yl)indolin-2-ones is reported via a one-pot three-component reaction of 3-phenacylidenoxindoles, tryptamine, and dimedone under ultrasound irra

Design, synthesis and QSAR study of novel isatin analogues inspired Michael acceptor as potential anticancer compounds

Molecular hybridization is considered as an effective tactic to develop drugs for the treatment of cancer. A series of novel hybrid compounds of isatin and Michael acceptor were designed and synthesized on the basis of association principle. These hybrid compounds were tested for cytotoxic potential against human cancer cell lines namely, BGC-823, SGC-7901 and NCI-H460 by MTT assay. Most compounds showed good anti-growth activities in all tested human cancer cells. SAR and QSAR analysis may provide vital information for the future development of novel anti-cancer inhibitors. Notably, compound 6a showed potent growth inhibition on BGC-823, SGC-7901 and NCI-H460 with the IC50 values of 3.6 ± 0.6, 5.7 ± 1.2, 3.2 ± 0.7 μM, respectively. Besides, colony formation assays, wound healing assays and flow cytometry analysis indicated 6a exhibited a potent anti-growth and anti-migration ability in a concentration-dependence manner through arrested cells in the G2/M phase of cell cycle. Moreover, 6a significantly repressed tumor growth in a NCI-H460 xenograft mouse model. Overall, our findings suggested isatin analogues inspired Michael acceptor may provide promising lead compounds for the development of cancer chemotherapeutics.

Application of isatin analogues in preparing antineoplastic drugs

The invention belongs to the field of medicinal chemistry, and in particular relates to an application of isatin analogues in preparing antineoplastic drugs. A series of isatin analogues can be synthesized by splicing isatin and [alpha],[beta]-unsaturated ketone via a medicinal chemistry splicing principle. The compounds (the isatin analogues) are relatively good in inhibitory activity on three tumor cells, and an antineoplastic effect can be achieved by inhibiting growth and migration of tumor cells and by blocking cell cycle G2/M period; and based upon in vivo experimental results, it is also indicated that the compounds can inhibit tumor growth.

Synthesis and biological evaluation of spiro[cyclopropane-1,3′-indolin]-2′-ones as potential anticancer agents

Libraries of spiro[cyclopropane-1,3′-indolin]-2′-ones were synthesized and evaluated for their biological activity against five different human cancer cell lines HT-29 (colon cancer), DU-145 (prostate cancer), Hela (cervical cancer), A-549 (Lung cancer),

Photophysical study of some 3-benzoylmethyleneindol-2-ones and estimation of ground and excited states dipole moments from solvatochromic methods using solvent polarity parameters

3-Benzoylmethyleneindol-2-ones, isatin based chalcones containing donor and acceptor moieties that exhibit excited-state intramolecular charge transfer, have been studied in different solvents by absorption and emission spectroscopy. The excited state beh

One-pot synthesis of new spiro[cyclopropane-1,3′-[3H]indol]- 2′(1′H)-ones from 3-phenacylideneoxindoles

(Chemical Equation Presented) In a one-pot procedure, the 3-phenacylideneoxindoles 1a-d were reacted with hydrazine and then in situ with lead(IV) acetate and new diastereoisomers of spiro[cyclopropane-1,3′-[3H] indol]-2′(1′H)-ones were prepared. Compounds 1a-d underwent a highly diastereoselective cyclopropanation leading to diastereoisomers 2a-d. These new compounds containing both 2-oxindole and cyclopropane moieties may be valuable in medicinal chemistry.

Reaction of isatins with acylmethylenetriphenylphosphoranes

The Wittig reaction of isatin, 5-bromoisatin, and 1-acetylisatin with methoxycarbonyl- or aroylmethylenetriphenylphosphoranes proceeds regioselectively to give Z- or combined Z- and E-isomeric 3-acetylmethyleneindol-2-ones. Ethoxymethylenetriphenylphospho