93218-76-9

Upstream product

• 71811-14-8 D-Glutaminsaeure-α-amid-γ-benzylester 
• 66025-93-2 (S)-1-(((R)-1-amino-5-(benzyloxy)-1,5-dioxopentan-2-yl)amino)-1-oxopropan-2-aminium 2,2,2-trifluoroacetate 
• 72009-73-5 N-acetyl-1-O-benzyl-4,6-O-benzylidene-α-muramic acid HONB ester 
• 35793-73-8 N-(tert-butyloxycarbonyl)-γ-benzyl-D-glutamic acid 
• 18814-49-8 tert-butoxycarbonyl-L-alanyl-D-isoglutamine benzyl ester 
• 18800-73-2 benzyl (R)-5-amino-4-((tert-butoxycarbonyl)amino)-5-oxopentanoate 
• 62853-36-5 L-alanyl-(γ-benzyl ester D-isoglutamine) 
• 74842-55-0 N-acetyl-1-O-benzyl-4,6-O-benzylidenemuramic acid 

Downstream Products

• 56772-92-0 muramyl dipeptide 

Relevant academic research and scientific papers

SYNTHESIS AND FAST-ATOM-BOMBARDMENT-MASS SPECTROMETRY OF N-ACETYLMURAMOYL-L-ALANYL-D-ISOGLUTAMINE (MDP)

N-Acetylmuramoyl-L-alanyl-D-isoglutamine (MDP) was synthesized by a series of condensation of appropriate reagents, followed by hydrogenolysis.Each intermediate step resulted in a stable, crystalline product.D-Isoglutamine 4-benzyl ester was condensed with N-(tert-butoxycarbonyl)-L-alanine N-hydroxysuccinimide ester, to give N-(tert-butoxycarbonyl)-L-alanyl-D-isoglutamine benzyl ester.Condensation of L-alanyl-D-isoglutamine benzyl ester with N-acetyl-1-O-benzyl-4,6-O-benzylidenemuramic acid, followed by hydrogenolysis, gave MDP.The synthetic scheme was shown to be capable of producing gram quantities of highly pure MDP, as well as a few of its analogs.The synthetic MDP was characterized by analytical and biological methods, and it was found that the use of fast-atom-bombardment-mass spectrometry may greatly simplify the characterization process.