56820-24-7

Upstream product

• 124-41-4 sodium methylate 
• 219786-83-1 4-Phenyl-5-(2,2,2-trichloro-acetyl)-1,4-dihydro-pyridine-3-carboxylic acid methyl ester 
• 93-60-7 methyl 3-pyridinecarboxylate 
• 100-52-7 benzaldehyde 
• 922-67-8 propynoic acid methyl ester 

Downstream Products

• 120533-74-6 5-Methoxythiocarbonyl-4-phenyl-1,4-dihydro-pyridine-3-carboxylic acid methyl ester 
• 120533-66-6 4-Phenyl-1,4-dihydro-pyridine-3,5-dicarbothioic acid di-O-methyl ester 
• 252669-41-3 dimethyl 1-tert-butyloxycarbonyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate 
• 252669-39-9 dimethyl 1,4-dihydro-1-methoxycarbonyl-4-phenylpyridine-3,5-dicarboxylate 
• 210427-45-5 tetramethyl-6,12-diphenyl-3,9-diazahexacyclo<6.4.0.0(2,7).0(4,11).0(5,10)>dodecane-1,5,7,11-tetracarboxylate 
• 1243247-96-2 dimethyl 4-phenyl-1-(4-picolyl)-1,4-dihydropyridine-3,5-dicarboxylate 

Relevant academic research and scientific papers

Photodimerization of 4-Aryl-1,4-dihydropyridines in 1-Butyl-3-methylimidazolium tetrafluoroborate

A simple, efficient, and convenient method for the photodimerization of 4-aryl-1,4-dihydropyridine in room-temperature ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate ([Bmim][BF4]) has been developed. By this way, head-to-tail syn-di

A Cofactor-Substrate-Based Supramolecular Fluorescent Probe for the Ultrafast Detection of Nitroreductase under Hypoxic Conditions

Identifying the location and expression levels of enzymes under hypoxic conditions in cancer cells is vital in early-stage cancer diagnosis and monitoring. By encapsulating a fluorescent substrate, L-NO2, within the NADH mimic-containing metal–organic capsule Zn-MPB, we developed a cofactor-substrate-based supramolecular luminescent probe for ultrafast detection of hypoxia-related enzymes in solution in vitro and in vivo. The host–guest structure fuses the coenzyme and substrate into one supramolecular probe to avoid control by NADH, switching the catalytic process of nitroreductase from a double-substrate mechanism to a single-substrate one. This probe promotes enzyme efficiency by altering the substrate catalytic process and enhances the electron transfer efficiency through an intra-molecular pathway with increased activity. The enzyme content and fluorescence intensity showed a linear relationship and equilibrium was obtained in seconds, showing potential for early tumor diagnosis, biomimetic catalysis, and prodrug activation.

Ultrasound-mediated synthesis of 4-substituted 1,4-dihydropyridine-3,5- dicarboxylates catalyzed by 1-carboxymethyl-3-methylimidazolium tetrafluoroborate under solvent free condition

4-Substituted 1,4-dihydropyridine-3,5-dicarboxylates (4) have been synthesized by the solvent-free reaction of aldehyde, methyl propiolate and ammonium carbonate catalyzed by ionic liquid 1-carboxymethyl-3-methylimidazolium tetrafluoroborate under ultraso

Synthesis of 3-5-diacyl-4-phenyl-1,4-dihydropyridines

3,5-Diacyl-4-phenyl-1,4-dihydropyridines have been synthesized via a regio- and chemoselective addition of Ph2Cu(CN)Li2 to β-substituted N- alkylpyridinium salts, followed by acylation of the intermediate 1,4- dihydropyridines with t