56844-42-9

Usage

Chemical class

Thienopyrimidines

Structure

Heterocyclic aromatic compound containing a thieno[2,3-d]pyrimidine core with chlorine at the 6th position and methyl at the 5th position

Uses

Intermediate in synthesis of pharmaceutical compounds and agrochemicals

Properties

Valuable building block for bioactive molecules in pharmaceutical and agricultural industries

Activities

Exhibits antifungal and antibacterial activities, potential uses in medicine and agriculture.

Upstream product

• 43088-64-8 5-Methyl-3,4-dihydrothieno<2,3-d>pyrimid-4-one 
• 31891-06-2 ethyl 2-aminothiophene-3-carboxylate 
• 43088-64-8 5-methylthieno[2,3-d]pyrimidin-4-ol 
• 43088-42-2 2-amino-4-methyl-thiophene-3-carboxylic acid ethyl ester 

Downstream Products

• 56844-14-5 4,6-dichloro-5-methylthieno[2,3-d]pyrimidine 
• 1332721-14-8 2-(6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-ylamino)-5-fluorophenol 
• 1332720-87-2 (6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-[4-fluoro-2-((R)-piperidin-3-yloxy)-phenyl]-amine hydrochloride 
• 1332720-88-3 (6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-[4-fluoro-2-((R)-1-methanesulfonylpiperidin-3-yloxy)-phenyl]-amine 
• 1332720-94-1 {2-[2-(6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-ylamino)-5-fluoro-phenoxy]-propyl}-carbamic acid tert-butyl ester 
• 1332720-97-4 N-{2-[2-(6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-ylamino)-5-fluoro-phenoxy]-propyl}-acetamide 
• 1365060-91-8 2-((6-chloro-5-methylthieno[2,3-d]pyrimidin-4-yl)thio)acetic acid 
• 56844-28-1 benzyl-(6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-amine 

Relevant academic research and scientific papers

Computer-aided identification, synthesis and evaluation of substituted thienopyrimidines as novel inhibitors of HCV replication

A structure-based virtual screening technique was applied to the study of the HCV NS3 helicase, with the aim to find novel inhibitors of the HCV replication. A library of ～450000 commercially available compounds was analysed in silico and 21 structures were selected for biological evaluation in the HCV replicon assay. One hit characterized by a substituted thieno-pyrimidine scaffold was found to inhibit the viral replication with an EC50value in the sub-micromolar range and a good selectivity index. Different series of novel thieno-pyrimidine derivatives were designed and synthesised; several new structures showed antiviral activity in the low or sub-micromolar range.

HALOGEN OR CYANO SUBSTITUTED THIENO [2,3-D]PYRIMIDINES HAVING MNK1/MNK2 INHIBITING ACTIVITY FOR PHARMACEUTICAL COMPOSITIONS

The present invention relates to novel thienopyhmidine compounds of general formula (I), pharmaceutical compositions comprising these compounds and their therapeutic use for the prophylaxis and/or treatment of diseases which can be influenced by the inhib

New piperidinylamino-thieno[2,3-D] pyrimidine compounds

The invention relates to 5-HT receptor antagonists. Novel piperidinylamino-thieno [2,3-d]pyrimidine compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed.

Piperidinylamino-thieno[2,3-D] pyrimidine compounds

The invention relates to 5-HT receptor modulators, particularly 5-HT2B antagonists. Novel piperidinylamino-thieno [2,3-d] pyrimidine compounds represented by Formula I, II and III, and uses thereof for treating conditions including pulmonary ar