43088-64-8Relevant articles and documents
Pd-containing IL-based ordered nanostructured organosilica: A powerful and recoverable catalyst for Sonogashira reaction
Shaker, Masoumeh,Elhamifar, Dawood
supporting information, (2020/10/30)
An IL-based ordered nanostructured organosilica supported palladium (Pd@ONO-IL) is synthesized and characterized. The Pd@ONO-IL was used as powerful nanocatalyst in the Sonogashira reaction that the corresponding products were obtained in high yield. The
Computer-aided identification, synthesis and evaluation of substituted thienopyrimidines as novel inhibitors of HCV replication
Bassetto, Marcella,Leyssen, Pieter,Neyts, Johan,Yerukhimovich, Mark M.,Frick, David N.,Brancale, Andrea
supporting information, p. 31 - 47 (2016/08/01)
A structure-based virtual screening technique was applied to the study of the HCV NS3 helicase, with the aim to find novel inhibitors of the HCV replication. A library of ~450000 commercially available compounds was analysed in silico and 21 structures were selected for biological evaluation in the HCV replicon assay. One hit characterized by a substituted thieno-pyrimidine scaffold was found to inhibit the viral replication with an EC50value in the sub-micromolar range and a good selectivity index. Different series of novel thieno-pyrimidine derivatives were designed and synthesised; several new structures showed antiviral activity in the low or sub-micromolar range.
HALOGEN OR CYANO SUBSTITUTED THIENO [2,3-D]PYRIMIDINES HAVING MNK1/MNK2 INHIBITING ACTIVITY FOR PHARMACEUTICAL COMPOSITIONS
-
Page/Page column 39, (2011/09/30)
The present invention relates to novel thienopyhmidine compounds of general formula (I), pharmaceutical compositions comprising these compounds and their therapeutic use for the prophylaxis and/or treatment of diseases which can be influenced by the inhib