43088-64-8

Usage

Chemical Properties

Gray solid

InChI:InChI=1/C7H6N2OS/c1-4-2-11-7-5(4)6(10)8-3-9-7/h2-3H,1H3,(H,8,9,10)

Upstream product

• 101667-97-4 5-Methyl-3,4-dihydrothieno<2,3-d>pyrimid-4-one-6-carboxylic acid 
• 17417-67-3 3,4-Dihydro-5-methyl-4-oxothieno<2,3-d>pyrimidin-6-carbonsaeure-ethylester 
• 43088-42-2 2-amino-4-methyl-thiophene-3-carboxylic acid ethyl ester 
• 77287-34-4 formamide 
• 4651-98-3 2-amino-4-methylthiophene-3-carboxylic acid methyl ester 
• 3473-63-0 formamidine acetic acid 
• 31891-06-2 ethyl 2-aminothiophene-3-carboxylate 
• 4623-55-6 2-amino-4-methylthiophene-3-carbonitrile 
• 64-18-6 formic acid 

Downstream Products

• 56844-48-5 5-methyl-3-(2-oxo-propyl)-3H-thieno[2,3-d]pyrimidin-4-one 
• 19678-89-8 5-methyl-3-(2-oxo-2-phenyl-ethyl)-3H-thieno[2,3-d]pyrimidin-4-one 
• 43088-67-1 4-chloro-5-methylthieno[2,3-d]pyrimidine 
• 19678-80-9 3-benzyl-5-methyl-3H-thieno[2,3-d]pyrimidin-4-one 
• 19673-91-7 4-Brom-5-methyl-thieno<2,3-d>pyrimidin 
• 56844-42-9 6-chloro-5-methylthieno[2,3-d]pyrimidin-4(3H)-one 
• 19673-90-6 6-Bromo-5-methyl-4-methoxythieno<2,3-d>pyrimidine 
• 56844-14-5 4,6-dichloro-5-methylthieno[2,3-d]pyrimidine 
• 1332721-14-8 2-(6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-ylamino)-5-fluorophenol 
• 1332720-87-2 (6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-[4-fluoro-2-((R)-piperidin-3-yloxy)-phenyl]-amine hydrochloride 
• 1332720-88-3 (6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-[4-fluoro-2-((R)-1-methanesulfonylpiperidin-3-yloxy)-phenyl]-amine 
• 1332720-94-1 {2-[2-(6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-ylamino)-5-fluoro-phenoxy]-propyl}-carbamic acid tert-butyl ester 
• 1332720-97-4 N-{2-[2-(6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-ylamino)-5-fluoro-phenoxy]-propyl}-acetamide 
• 56844-42-9 6-chloro-5-methylthieno[2,3-d]pyrimidin-4-ol 

Relevant academic research and scientific papers

Pd-containing IL-based ordered nanostructured organosilica: A powerful and recoverable catalyst for Sonogashira reaction

An IL-based ordered nanostructured organosilica supported palladium (Pd@ONO-IL) is synthesized and characterized. The Pd@ONO-IL was used as powerful nanocatalyst in the Sonogashira reaction that the corresponding products were obtained in high yield. The

Hetero-aromatic compound and its use in medicine

The invention provides a hetero-aromatic compound or a stereisomer, geometric isomer, tautomer, despinner, nitrogen oxide, hydrate, solvate, metabolite, metabolism precursor and pharmaceutically acceptable salt or prodrug thereof, which is used for treating proliferative diseases. The invention also discloses a pharmaceutical composition containing the compound and an application of the compound or pharmaceutical composition thereof in preparation of a medicine for treating proliferative diseases.

Computer-aided identification, synthesis and evaluation of substituted thienopyrimidines as novel inhibitors of HCV replication

A structure-based virtual screening technique was applied to the study of the HCV NS3 helicase, with the aim to find novel inhibitors of the HCV replication. A library of ～450000 commercially available compounds was analysed in silico and 21 structures were selected for biological evaluation in the HCV replicon assay. One hit characterized by a substituted thieno-pyrimidine scaffold was found to inhibit the viral replication with an EC50value in the sub-micromolar range and a good selectivity index. Different series of novel thieno-pyrimidine derivatives were designed and synthesised; several new structures showed antiviral activity in the low or sub-micromolar range.

Discovery of a novel series of thienopyrimidine as highly potent and selective PI3K inhibitors

Inhibition of the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway provides a promising new approach for cancer therapy. Through a rational design, a novel series of thienopyrimidine was discovered as highly pote

HALOGEN OR CYANO SUBSTITUTED THIENO [2,3-D]PYRIMIDINES HAVING MNK1/MNK2 INHIBITING ACTIVITY FOR PHARMACEUTICAL COMPOSITIONS

The present invention relates to novel thienopyhmidine compounds of general formula (I), pharmaceutical compositions comprising these compounds and their therapeutic use for the prophylaxis and/or treatment of diseases which can be influenced by the inhib

Synthesis and anti-tumor activities of N′-benzylidene-2-(4- oxothieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone derivatives

A compound with a cyclic thienopyrimidine moiety and an aceto-hydrazone moiety in its chemical structure was discovered in a cell-based screening to have noticeable cytotoxicity on several tumor cell lines. A total of 38 derivatives of this compound were

AlCl3-induced (hetero)arylation of thienopyrimidine ring: a new synthesis of 4-substituted thieno[2,3-d]pyrimidines

AlCl3 facilitated C-C bond forming reaction between 4-chloro-thieno[2,3-d]pyrimidines and (hetero)arenes affording a direct and single-step method for the synthesis of 4-(hetero)aryl substituted thieno[2,3-d]pyrimidines. A number of novel thien

Synthesis of some new condensed thiophenes and their antimicrobial activity

New condensed thiophene derivatives such as 3-methyl-5,6,7,8- hexahydrothieno [2,3-b] quinoline-4-amine (2),methyl 4-amino-3,6-dimethyl thieno [2,3-b] pyridine-5-carboxylate (3), 5-methylthieno [2,3-d] pyrimidine-4-amine (4) and 5-methyl-3,4-dihydrothieno [2,3-d] pyrimidine-4-one (5) were synthesized from 4-methyl-2-aminothiophene-3-carbonitrile. All the synthesized compounds were characterized on the basis of their IR, 1H NMR and mass spectral data and screened for their antimicrobial activity.

NOVEL THIENOPYRIMIDINE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to a novel thienopyrimidine derivative having an excellent anti? inflammatory and anti-cancer activity, or a pharmaceutically acceptable salt thereof, a process for the preparation thereof and a pharmaceutical composition comprising the same. The compound according to the present invention strongly inhibits IKB kinase-β (IKK-β) involved in the activation of a transcriptional factor, NF-κB, which is associated with inducing various immune and inflammatory diseases, whereby a composition comprising the compound is a useful therapeutic agent against inflammatory diseases, in particular, arthritis and cancer.

SUBSTITUTED AMINOPYRIMIDINES AS NEUROKININ ANTAGONISTS

The invention discloses tachykinin receptor antagonists. The tachykinin family of receptors comprising the neurokinins substance P (SP), neurokinin A, and neurokinin B and related neuropeptides that are widely distributed in the peripheral and central ner