56849-88-8

Usage

Uses

Used in Organic Synthesis:
1-DIMETHYLAMINO-3-(TRIMETHYLSILYL)-2-PROPYNE is used as a reagent in organic synthesis for its ability to undergo multiple types of reactions, facilitating the creation of a wide array of organic compounds.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 1-DIMETHYLAMINO-3-(TRIMETHYLSILYL)-2-PROPYNE is utilized as a key intermediate in the synthesis of various drugs, leveraging its unique chemical properties to contribute to the development of new medicinal compounds.
Used in Agrochemicals:
1-DIMETHYLAMINO-3-(TRIMETHYLSILYL)-2-PROPYNE is employed in the production of agrochemicals, where its reactivity and stability are harnessed to create effective products for agricultural applications.
Used in Electronic Materials:
1-DIMETHYLAMINO-3-(TRIMETHYLSILYL)-2-PROPYNE also finds use in the manufacturing of electronic materials, where its specific properties are crucial for the development of advanced electronic components and systems.
Overall, 1-DIMETHYLAMINO-3-(TRIMETHYLSILYL)-2-PROPYNE plays a significant role in a variety of applications due to its unique structure and reactivity, making it a valuable asset in research and industrial processes.

Upstream product

• 50-00-0 formaldehyd 
• 124-40-3 dimethyl amine 
• 1066-54-2 trimethylsilylacetylene 
• 75-09-2 dichloromethane 
• 506-59-2 N,N-dimethylammonium chloride 
• 7223-38-3 N,N-Dimethylpropargylamin 
• 75-77-4 chloro-trimethyl-silane 

Downstream Products

• 31683-47-3 1-(trimethylsilyl)-3-phenylprop-1-yne 
• 62752-97-0 1-(1-Dimethylamino-3-trimethylsilanyl-prop-2-ynyl)-cyclohexanol 
• 62752-96-9 2-Dimethylamino-4-trimethylsilanyl-but-3-yn-1-ol 

Relevant academic research and scientific papers

Practical synthesis of silyl-protected and functionalized propargylamines using nanostructured Ag/TiO2 and Pt/TiO2 as active recyclable catalysts

Abstract: Herein we report the use of Ag/TiO2 and Pt/TiO2 nanocatalysts to promote the synthesis of a series of silyl-protected and functionalized propargylamine derivatives through alkyne–amine–aldehyde (A3) coupling unde

Mechanistic insights into the one-pot synthesis of propargylamines from terminal alkynes and amines in chlorinated solvents catalyzed by gold compounds and nanoparticles

Propargylamines can be obtained from secondary amines and terminal alkynes in chlorinated solvents by a three-and two-component synthesis catalyzed by gold compounds and nanoparticles (Au-NP) under mild conditions. The use of dichloromethane allows for the activation of two C-Cl bonds and a clean transfer of the methylene fragment to the final product. The scope of the reaction as well as the influence of different gold(III) cycloaurated complexes and salts has been investigated. The involvement of gold nanoparticles generated in situ in the process is discussed and a plausible reaction mechanism is proposed on the basis of the data obtained.

Mild and efficient synthesis of propargylamines by copper-catalyzed Mannich reaction

Terminal alkynes can be condensed with aqueous formaldehyde and primary or secondary amines to give secondary and tertiary propargylamines. The reaction is best carried out in DMSO under CuI catalysis. Terminal alkynes undergo mild and efficient aminomethylation with aqueous formaldehyde and secondary amines under CuI catalysis. In most cases high to nearly quantitative yields of tertiary propargylamines are obtained in DMSO solution at room temperature. Aromatic, aliphatic and silylated acetylenes as well as alkynols can be used. Primary amines are less reactive and satisfactory yields of secondary propargylamines are obtained only with phenylacetylene.

Studies of Tertiary Amine Oxides Part 10. Silylated Acetylenic Amines and the Corresponding N-Oxides

Ten silylated acetylenic amines were synthesized and converted into the corresponding tertiary N-oxides by oxidation with m-chloroperbenzoic acid.All compounds were fully characterised by elemental and spectral analyses.The carbon-13 spectra of the silylated acetylenic amines and the N-oxides were analysed and the N-oxidation effect was calculated.