568599-53-1Relevant articles and documents
NOVEL SLOW-WAVE SLEEP INDUCING AGENT
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Paragraph 0093; 0094; 0095; 0096, (2019/07/29)
PROBLEM TO BE SOLVED: To provide a sleep inducing agent that induces slow-wave sleep (SWS) without causing side effects such as a cardiovascular action. SOLUTION: A slow-wave sleep inducing agent is provided that includes a compound represented by formula (I) or pharmaceutically acceptable salt thereof (R1 is a carboxyl group; m R2 independently represent a halogen atom, an alkyl group, a nitro group, an alkoxy group, a cyano group or an aryl group; n R3 independently represent a halogen atom, an alkyl group, a nitro group, an alkoxy group, a cyano group or an aryl group; m is 0, 1 or 2; n is 1 or 2). SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT
Silver(I)-catalyzed iodination of arenes: Tuning the lewis acidity of N-iodosuccinimide activation
Racys, Daugirdas T.,Sharif, Salaheddin A. I.,Pimlott, Sally L.,Sutherland, Andrew
, p. 772 - 780 (2016/02/18)
A mild and rapid method for the iodination of arenes that utilizes silver(I) triflimide as a catalyst for activation of N-iodosuccinimide has been developed. The transformation was found to be general for a wide range of anisole, aniline, acetanilide, and phenol derivatives and allowed the late-stage iodination of biologically active compounds such as PIMBA, a SPECT imaging agent of breast cancer, and (a?)-IBZM, a dopamine D2 receptor antagonist. The method was also modified for the radioiodination of arenes using a one-pot procedure involving the in situ generation of [125I]-N-iodosuccinimide followed by the silver(I)-catalyzed iodination.
N-(4-substituted phenyl)-anthranilic acid hydroxamate esters
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Page 26, (2010/02/05)
The present invention relates to oxygenated esters of 4-substituted-phenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof.
