56882-42-9Relevant academic research and scientific papers
Antidepressant activity of 5-aryl-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ols
Houlihan,Gogerty,Parrino,Ryan
, p. 765 - 768 (2007/10/02)
A series of 5-aryl-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ols was prepared and evaluated for potential antidepressant activity in the reserpine-induced hypothermia model and selected central nervous system and autonomic activity tests. Several members of the series, notably the 4-chloro- and 4-fluorophenyl analogues, demonstrated pharmacological activity in the range of imipramine. Both compounds provided a marked potentiation of the 5-hydroxytryptophan-facilitated monosynaptic spike in the spinal cat preparation.
Directed Lithiation of 2-Phenyl- and 2-(o-Methylphenyl)imidazoline
Houlihan, William J.,Parrino, Vincent A.
, p. 5177 - 5180 (2007/10/02)
2-Phenyl- and 2-(o-methylphenyl)imidazoline have been converted into their ortho- and α-lithiated species, respectively, by treatment with n-BuLi-hexane in THF.Treatment of these reagents with a variety of nucleophiles gave ortho- and α-substituted products.
Imidazo[2,1-a]isoquinolines
-
, (2008/06/13)
Imidazo[2,1-a]isoquinolines useful as anorexics and antidepressants are prepared from a dilithium derivative of a 2-(o-tolyl)-2-imidazoline.
