569354-59-2Relevant academic research and scientific papers
A potent and orally active HIV-1 integrase inhibitor
Egbertson, Melissa S.,Moritz, H. Marie,Melamed, Jeffrey Y.,Han, Wei,Perlow, Debra S.,Kuo, Michelle S.,Embrey, Mark,Vacca, Joseph P.,Zrada, Matthew M.,Cortes, Amanda R.,Wallace, Audrey,Leonard, Yvonne,Hazuda, Daria J.,Miller, Michael D.,Felock, Peter J.,Stillmock, Kara A.,Witmer, Marc V.,Schleif, William,Gabryelski, Lori J.,Moyer, Gregory,Ellis, Joan D.,Jin, Lixia,Xu, Wei,Braun, Matthew P.,Kassahun, Kellem,Tsou, Nancy N.,Young, Steven D.
, p. 1392 - 1398 (2007/10/03)
A 1,6-naphthyridine inhibitor of HIV-1 integrase has been discovered with excellent inhibitory activity in cells, good pharmacokinetics, and an excellent ability to inhibit virus with mutant enzyme.
HIV integrase inhibitors
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Page/Page column 13, (2010/11/27)
The invention encompasses a series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
Preparation of 2-aminomethyl-5-fluorobenzamides
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Page 18, (2008/06/13)
Benzamide compounds of Formula VII are prepared by reacting a benzoate compound of Formula V with an amine to obtain a benzamide compound of Formula VI, and then treating the benzamide VI with an amine deprotecting agent to obtain the benzamide VII; where
