57000-63-2

Basic information

• Product Name: 2-(3-chlorophenyl)-5-phenyl-1,3-oxazole
• CAS NO: 57000-63-2
• Molecular Formula: C₁₅H₁₀ClNO
• Molecular Weight: 255.699
• Mol File: 57000-63-2.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 421.7°C at 760 mmHg
• Flash Point: 208.8°C
• Density: 1.229g/cm³
• Vapor Pressure: 6.28E-07mmHg at 25°C
• Refractive Index: 1.595
• CAS DataBase Reference: 2-(3-chlorophenyl)-5-phenyl-1,3-oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-chlorophenyl)-5-phenyl-1,3-oxazole(57000-63-2)
• EPA Substance Registry System: 2-(3-chlorophenyl)-5-phenyl-1,3-oxazole(57000-63-2)

Safety Data

• Hazardous Substances Data: 57000-63-2(Hazardous Substances Data)

Usage

Type of compound

Aromatic heterocyclic compound

Oxazole family

Characterized by a five-membered ring containing one oxygen and one nitrogen atom

Substituents

3-chlorophenyl group and a phenyl group attached to the oxazole ring

Structural properties

Distinct structure due to the presence of the substituents

Chemical properties

Unique reactivity because of the substituents and oxazole ring

Applications

Organic synthesis, medicinal chemistry research, pharmaceutical development, biologically active compounds, agrochemicals, and material science.

Upstream product

• 38925-71-2 β-(m-chlorbenzamido)ethylbenzol 
• 536-74-3 phenylacetylene 
• 4070-53-5 3-chloro-N-hydroxybenzamide 
• 618-46-2 m-Chlorobenzoyl chloride 
• 22966-13-8 3-(3-chlorophenyl)-1-phenylprop-2-en-1-one 
• 34158-71-9 3-chlorobenzaldehyde oxime 
• 122-78-1 phenylacetaldehyde 
• 618-48-4 3-chlorobenzamide 
• 98-86-2 acetophenone 
• 1074-12-0 phenylglyoxal hydrate 
• 1075-06-5 2,2-dihydroxy-1-phenyl-ethanone 
• 4152-90-3 m-chlorobenzylamine 
• 100-42-5 styrene 
• 5468-37-1 2-aminoacetophenone hydrochloride 

Relevant articles and documents

Metal-free iodine(iii)-promoted synthesis of 2,5-diaryloxazoles

A nonmetal-catalyzed oxidative cyclization to achieve 2,5-disubstituted oxazoles from inexpensive and readily available substituted chalcone, (diacetoxyiodo)benzene (PIDA) and ammonium acetate (NH4OAc) at room temperature is described. The reaction forms a variety of 2,5-diaryloxazoles in good to excellent yields with broad substrate scope under mild conditions without the requirement of ligands and additional bases.

Iodine catalysed intramolecular C(sp3)-H functionalization: synthesis of 2,5-disubstituted oxazoles from N-arylethylamides

Iodine catalyzed synthesis of 2,5-disubstituted oxazoles from N-arylethylamides through intramolecular C(sp3)-H functionalization under metal-free conditions is described. The method is tolerable to a wide range of substrates having a variety of functional groups with moderate to good yields of the products.

Convenient one-pot synthesis of 2,5-disubstituted oxazoles via a catalytic oxidative dehydrogenation of F3CSO3H·SiO 2-DDQ/CuCl2/LiCl

A facile one-pot synthesis of 2,5-disubstituted oxazoles was developed via cyclization of aldoximes and phenylacetylene then dehydrogenation oxidation. 2,3-dichloro-5,6-dicyano-1,4-benzoquinone was studied for the selective oxidation of oxazolines using Cu2+/Li+ as catalyst and O2 as indirect oxidant. The reaction results showed that this catalyst system can effectively catalyze the oxidation of oxazolines to the corresponding oxazoles. Thus, a variety of polysubstituted oxazoles was easily synthesized in high yields by catalytic oxidation of 2,3-dichloro-5,6-dicyano-1, 4-benzoquinone/CuCl2/LiCl/O2.