57009-53-7

Upstream product

• 16357-40-7 3-acetyl-4-hydroxybenzoic acid 
• 74442-98-1 5-(2,2-Diacetylvinyl)-1,3-dimethyluracil 
• 2345-34-8 4-acetyloxy-benzoic acid 
• 13031-45-3 ethyl 4-acetoxybenzoate 
• 4869-46-9 1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde 
• 123-54-6 acetylacetone 
• 141-52-6 sodium ethanolate 

Downstream Products

• 1026852-20-9 4-Hydroxy-3-(3-oxo-3-quinolin-2-yl-propionyl)-benzoic acid ethyl ester 
• 1242248-34-5 (E)-ethyl 4-hydroxy-3-(3-(4-(4-phenoxybutoxy)phenyl)acryloyl)benzoate 
• 105639-12-1 5-{5-[4-(4,5-Dihydro-2-oxazolyl)-2-acetylphenoxy]pentyl}-3-methylisoxazole 
• 105639-25-6 2-acetyl-4-(4,5-dihydro-2-oxazolyl)phenol 
• 102298-02-2 ethyl 3-acetyl-5-cyano-4-hydroxybenzoate 
• 90844-13-6 4-hydroxyisophthalic acid 1-ethyl ester 
• 65372-54-5 2,2-dimethyl-4-chromanone-6-carboxylic acid 
• 102298-00-0 ethyl 3-acetyl-5-bromo-4-hydroxybenzoate 

Relevant academic research and scientific papers

Synthesis and insecticidal activity of chromanone and chromone analogues of diacylhydrazines

Diacylhydrazine derivatives have been identified as one of the most important insect growth regulators. A variety of diacylhydrazine derivatives were designed and synthesized in recent years due to their unique action mechanism, simple structure, and environmental benign character. This paper describes the molecular design, synthesis, and insecticidal activities of a series of chromanone and chromone analogues of diacylhydrazine derivatives. The preliminary bioassay showed that some of the chromanone analogues exhibited good insecticidal activity against Mythima separata at the dosage of 500 mg L-1. The present work demonstrated that replacement of the chroman ring of ANS-118, a commercial insecticide, with chromanone moiety could result in new compounds with high potent insecticidal activity.

Pyrimidine Derivatives and Related Compounds. 39. A Novel Cycloaromatization Reaction of 5-Formyl-1,3-dimethyluracil with Three-Carbon Nucleophiles. Synthesis of Substituted 4-Hydroxybenzoates

Treatment of 5-formyl-1,3-dimethyluracil (1) with α-substituted acetone derivatives (C-C-C type nucleophiles) such as acetylacetone, acetoacetamide, ethyl acetoacetate, and phenylacetone in basic media affords the corresponding 4-hydroxybenzoates (4).On the other hand, treatment of 1 with cyanoacetamide, a C-C-N type nucleophile, gives the nicotinate 8.A mechanism for this cycloaromatization was proposed on the basis of reaction of 5-formyl-1,3-dimethyluracil-d1 (6) with acetylacetone.

A Novel Ring Transformation of Uracil into the Benzene Ring System

Reaction of 5-formyl-1,3-dimethyluracil with some active methylene compounds in the presence of base causes novel ring transformations to give the p-hydroxybenzoates and the nicotinate.