57011-90-2Relevant academic research and scientific papers
A sustainable self-reproducing liposome consisting of a synthetic phospholipid
Matsuo, Muneyuki,Ohyama, Shota,Sakurai, Kotoba,Toyota, Taro,Suzuki, Kentaro,Sugawara, Tadashi
, p. 1 - 7 (2019)
A novel phosphoric membrane lipid (phospholipid) bearing an oleyl group as one of the hydrophobic chains formed a liposome with a thin lamella in water. Since the anionic membrane of pre-existing liposomes acted as a catalytic surface in phosphate buffer,
Derivatization of methylglyoxal for LC-ESI-MS analysis—stability and relative sensitivity of different derivatives
Fritzsche, Stefan,Billig, Susan,Rynek, Robby,Abburi, Ramarao,Tarakhovskaya, Elena,Leuner, Olga,Frolov, Andrej,Birkemeyer, Claudia
, (2018)
The great research interest in the quantification of reactive carbonyl compounds (RCCs), such as methylglyoxal (MGO) in biological and environmental samples, is reflected by the fact that several publications have described specific strategies to perform
NITRIC OXIDE RELEASING DERIVATIVES OF PARACETAMOL
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Page/Page column 5, (2010/09/18)
The present invention particularly relates to novel nitrate esters of paracetamol. The nitrate esters of paracetamol are prepared by reacting the paracetamol with dihaloalkyl compound and followed by reaction with silver nitrate to obtain the correspondin
NITRIC OXIDE RELEASING DERIVATIVES OF PARACETAMOL
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Page/Page column 10-11, (2009/04/25)
The present invention particularly relates to novel nitrate esters of paracetamol. The nitrate esters of paracetamol are prepared by reacting the paracetamol with dihaloalkyl compound and followed by reaction with silver nitrate to obtain the correspondin
Development of a selective ESI-MS derivatization reagent: Synthesis and optimization for the analysis of aldehydes in biological mixtures
Eggink, Mark,Wijtmans, Maikel,Ekkebus, Reggy,Lingeman, Henk,De Esch, Iwan J. P.,Kool, Jeroen,Niessen, Wilfried M. A.,Irth, Hubertus
experimental part, p. 9042 - 9051 (2009/06/06)
In LC-MS, derivatization is primarily used to improve ionization characteristics, especially for analytes that are not (efficiently) ionized by ESI or APCI such as aldehydes, sugars, and steroids. Derivatization strategies are then directed at the incorporation of a group with a permanent charge. A compound class that typically requires derivatization prior to LC-MS is the group of small aliphatic aldehydes that are, for instance, analyzed as the key biomarkers for lipid peroxidation in organisms. Here we report the development of a new tailor-made, highly sensitive, and selective derivatization agent 4-(2-(trimethylammonio)ethoxy)benzenaminium halide (4-APC) for the quantification of aldehydes in biological matrixes with positive ESI-MS/MS without additional extraction procedures. 4-APC possesses an aniline moiety for a fast selective reaction with aliphatic aldehydes as well as a quaternary ammonium group for improved MS sensitivity. The derivatization reaction is a convenient one-pot reaction at a mild pH (5.7) and temperature (10°C). As a result, an in-vial derivatization can be performed before analysis with an LC-MS/MS system. All aldehydes are derivatized within 30 min to a plateau, except malondialdehyde, which requires 300 min to reach a plateau. All derivatized aldehydes are stable for at least 35 h. Linearity was established between 10 and 500 nM and the limits of detection were in the 3-33 nM range for the aldehyde derivatives. Furthermore, the chosen design of these structures allows tandem MS to be used to monitor the typical losses of 59 and 87 from aldehyde derivatives, thereby enabling screening for aldehydes. Finally, of all aldehydes, pentanal and hexanal were detected at elevated levels in pooled healthy human urine samples.
A multi-mode-driven molecular shuttle: Photochemically and thermally reactive azobenzene rotaxanes
Murakami, Hiroto,Kawabuchi, Atsushi,Matsumoto, Rika,Ido, Takeshi,Nakashima, Naotoshi
, p. 15891 - 15899 (2007/10/03)
The shuttling process of α-CyD in three rotaxanes (1-3) containing α-cyclodextrin (α-CyD) as a ring, azobenzene as a photoactive group, viologen as an energy barrier for slipping of the ring, and 2,4-dinitrobenzene as a stopper was investigated. The trans
Preparation and Characterization of Base-Sensitive Destructible Surfactants
Jaeger, David A.,Finley, C. Timothy,Walter, Mark R.,Martin, Craig A.
, p. 3956 - 3959 (2007/10/02)
Destructible surfactants 4-n-C12H25C6H4SO2CH2CH2OC6H4X-4 (1, X = N+Me3, NO3-; 2, X = SO3-, K+) were prepared, and their stability/lability characteristics in aqueous micellar solutions with respect to E1cB elimination to give 4-n-C12H25C6H4SO2CH=CH2 (7) and HOC6H4X-4 (8/9) were determined by 1H NMR.In 0.001 and 0.1 M DCl, both 1 and 2 were stable for 24 h at 75 deg C.In D2O alone at 25 deg C, 1 slowly decomposed, and 2 was stable.At 25 deg C, 1 decomposed completely within 10 min in 0.1 M NaHCO3, whereas 2 was more stable in 0.1 M K2CO3.The difference in reactivities for 1 and 2 was ascribed to a combination of electronic and micellar effects.Support for the latter was found in a comparison of 2's behavior with that of 4-MeC6H4SO2CH2CH2OC6H4SO3Na-4 (10).
