96116-29-9Relevant academic research and scientific papers
Calixarene-mediated liquid membrane transport of choline conjugates 2: Transport of drug-choline conjugates and neurotransmitters
Adhikari, Birendra Babu,Roshandel, Sahar,Fujii, Ayu,Schramm, Michael P.
, p. 2683 - 2690 (2015)
Lower rim carboxylic acid calix[n]arenes and upper rim phosphonic acid functionalized calix[4]arenes effect selective transport of distinct molecular payloads through a liquid membrane. The secret to this success lies in the attachment of a receptor-complementary handle. We find that the trimethylammonium ethylene group present in choline is a general handle for the transport of drug and drug-like species. Furthermore, neurotransmitters possessing ionizable amine termini are also transported. Some limitations to this strategy have been uncovered as payloads become increasingly lipophilic. These developments reveal new approaches to synthetic receptor-mediated selective small molecule transport in vesicular and cellular systems. Ammonium species emerge as general and potent handles for effecting drug transport as mediated by ionizable calixarenes. Trimethylammonium, ammonium and ammonium carboxylates work in conjunction with phosphonic acid and carboxylic acid functionalized calix[n]arenes.
A sustainable self-reproducing liposome consisting of a synthetic phospholipid
Matsuo, Muneyuki,Ohyama, Shota,Sakurai, Kotoba,Toyota, Taro,Suzuki, Kentaro,Sugawara, Tadashi
, p. 1 - 7 (2019/04/27)
A novel phosphoric membrane lipid (phospholipid) bearing an oleyl group as one of the hydrophobic chains formed a liposome with a thin lamella in water. Since the anionic membrane of pre-existing liposomes acted as a catalytic surface in phosphate buffer,
