57012-86-9

Basic information

• Product Name: 1-ETHYLIMIDAZOLIDINE-2,4,5-TRIONE
• Synonyms: 1-ETHYLIMIDAZOLIDINE-2,4,5-TRIONE
• CAS NO: 57012-86-9
• Molecular Formula: C₅H₆N₂O₃
• Molecular Weight: 142.113
• Mol File: 57012-86-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Density: 1.381g/cm³
• Refractive Index: 1.504
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-ETHYLIMIDAZOLIDINE-2,4,5-TRIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ETHYLIMIDAZOLIDINE-2,4,5-TRIONE(57012-86-9)
• EPA Substance Registry System: 1-ETHYLIMIDAZOLIDINE-2,4,5-TRIONE(57012-86-9)

Safety Data

• Hazardous Substances Data: 57012-86-9(Hazardous Substances Data)

Usage

Uses

Ethyl-imidazolidinetrione?is a degradation product of?Cymoxanil?(C988995), which?is a fungicide applied as a seed treatment or as a foliar application to the plants to control late blight.

InChI:InChI=1/C5H6N2O3/c1-2-7-4(9)3(8)6-5(7)10/h2H2,1H3,(H,6,8,10)

Upstream product

• 79-37-8 oxalyl dichloride 
• 625-52-5 N-Ethylurea 
• 861071-57-0 N,N'-bis-ethylcarbamoyl-oxalamide 
• 623-76-7 N,N'-diethylurea 
• 57966-95-7 cymoxanil 

Downstream Products

• 625-52-5 N-Ethylurea 
• 144-62-7 oxalic acid 
• 1086764-91-1 C₁₁H₁₄N₂O₃ 
• 1207374-55-7 1-[(4,5-dioxo-3-phenyl-2-thioxoimidazolidin-1-yl)methyl]-3-ethyl-imidazolidine-2,4,5-trione 

Relevant articles and documents

Synthesis of imidazolidines, saccharins and chromone bearing imidazolidine ring

As a part of a research program related to the synthetic study of pharmacologically and agrochemically interesting imidazolidines, we synthesized imidazolidines 8, 9, 10, saccharins 12, 13 and chromone 17 bearing imidazolidine-2,4,5-trione or 2-thioxoimodazolidine-4,5-dione rings.

Characterization of metabolites of fungicidal cymoxanil in a sensitive strain of Botrytis cinerea

The metabolism of cymoxanil [1-(2-cyano-2-methoxyiminoacetyl)-3-ethyl urea] by a very sensitive strain of Botrytis cinerea toward this fungicide was studied by using [2-14C]-cymoxanil. Labeled cymoxanil was added either in a culture of this strain or in its enzymatic extract. The main metabolites, detected in biological samples, were isolated and identified by mass and NMR spectrometry. Their identification allowed us to show that this strain quickly metabolized cymoxanil according to at least three enzymatic pathways: (i) cyclization leading, after hydrolysis, to ethyl parabanic acid, (ii) reduction giving demethoxylated cymoxanil, and (iii) hydrolysis and reduction followed by acetylation leading to N-acetylcyanoglycine. In a cell-free extract of the same strain, only the first and the second enzymatic reactions, quoted above, occurred. Biological tests showed that, among all the metabolites, only N-acetylcyanoglycine is fungitoxic toward this sensitive strain.

Pharmaceutical composition containing an imidazolidinetrione derivative or pharmaceutically acceptable salt thereof

Pharmaceutical compositions containing imidazolidinetrione derivatives or pharmaceutically acceptable salts thereof having hypoglycemic and hypolipidemic effects. The compositions comprise as an active ingredient at least one imidazolidinetrione derivative of the formula: STR1 wherein each of R1 and R2, which may be the same or different, is hydrogen, an alkyl group, a cycloalkyl group or STR2 and each of R3 and R4, which may be the same or different, is hydrogen, halogen, a nitro group, a lower alkyl group or a lower alkoxy group.