57053-02-8

Basic information

• Product Name: diMethyl 2-aMinoisophthalate
• Synonyms: diMethyl 2-aMinoisophthalate;1,3-dimethyl 2-aminobenzene-1,3-dicarboxylate;dimethyl 2-aminobenzene-1,3-dioate
• CAS NO: 57053-02-8
• Molecular Formula: C₁₀H₁₁NO₄
• Molecular Weight: 209.19864
• Mol File: 57053-02-8.mol

Chemical Properties

• Melting Point: 102-103 °C
• Boiling Point: 309.3±22.0 °C(Predicted)
• Appearance: /
• Density: 1.248±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: -0.19±0.10(Predicted)
• CAS DataBase Reference: diMethyl 2-aMinoisophthalate(CAS DataBase Reference)
• NIST Chemistry Reference: diMethyl 2-aMinoisophthalate(57053-02-8)
• EPA Substance Registry System: diMethyl 2-aMinoisophthalate(57053-02-8)

Safety Data

• Hazardous Substances Data: 57053-02-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Fine Chemical Synthesis:
DiMethyl 2-aMinoisophthalate is used as an intermediate in the synthesis of various pharmaceutical and fine chemical compounds. Its unique chemical structure allows for the development of new drugs and specialty chemicals with specific therapeutic or functional properties.
Used in Dye and Pigment Production:
DiMethyl 2-aMinoisophthalate is used in the production of dyes and pigments due to its versatile chemical properties. Its ability to form stable complexes with other molecules makes it suitable for creating a wide range of colorants for various applications, including textiles, plastics, and inks.
Used in Polymer Production:
DiMethyl 2-aMinoisophthalate is also used in the production of polymers. Its chemical structure contributes to the formation of polymers with specific properties, such as improved strength, flexibility, or thermal stability, making them suitable for various industrial applications.

Upstream product

• 67-56-1 methanol 
• 99-31-0 5-aminoisophthalic acid 
• 39622-79-2 2-aminoisophthalic acid 
• 57052-99-0 dimethyl 2-nitroisophthalate 
• 21161-11-5 2-nitroisophthalic acid 
• 81-20-9 2,6-dimethylnitrobenzene 

Downstream Products

• 89207-99-8 2-(1-Pyrrolyl)isophtalsaeure-dimethylester 
• 1322091-04-2 C₂₀H₂₆N₂O₇ 

Relevant articles and documents

V-shaped chiral carboxylic acid ligand, preparation method and application thereof

The invention discloses a V-shaped chiral carboxylic acid ligand L-H2, relates to the technical field of synthetic chemistry and coordination chemistry, and also provides a preparation method of the ligand and an application of the ligand in assembling chiral complexes. The preparation method has the beneficial effects that the prepared V-shaped chiral carboxylic acid ligand is cheap in synthesis raw materials, simple in preparation method and suitable for large-scale preparation, has proper ligand rigidity and special coordination guidance and is beneficial to overcoming the flexibility of a framework of amino acid and the flexibility of a coordination mode. Therefore, a complex material with a chiral structure is easy to assemble.

SELF-IMMOLATIVE SYSTEMS

The present invention is concerned with self-immolative recognition and/or responsive systems for electrophilic compounds, especially alkylating agents, which systems may comprise disclosure or detection of the alkylating agent. The present invention is especially concerned with non-protic triggered self-immolative systems, molecules, and methods, and in particular for detection of non- protic electrophilic agents, and especially alkylating agents, for example alkyl or benzylic halides, which may be found in pesticides or fumigants, or chemical warfare agents.

Covalent Lipid Pocket Ligands Targeting p38α MAPK Mutants

A chemical genetic approach is presented to covalently target a unique lipid binding pocket in the protein kinase p38α, whose function is not yet known. Based on a series of cocrystal structures, a library of 2-arylquinazolines that were decorated with electrophiles were designed and synthesized to covalently target tailored p38α mutants containing artificially introduced cysteine residues. Matching protein–ligand pairs were identified by MS analysis and further validated by MS/MS studies and protein crystallography. The covalent ligands that emerged from this approach showed excellent selectivity towards a single p38α mutant and will be applicable as suitable probes in future studies of biological systems to dissect the function of the lipid pocket by means of pharmacological perturbations.

SYNTHESES OF N-HETEROCYCLIC CARBENES AND INTERMEDIATES THEREFOR

A method of preparing a 2,6 disubstituted anilines includes, reacting a 2-amino isophtha!ic acid diester with sufficient Grignard reagent R2CH2MgX to form the corresponding diol product, dehydrating the diol product to the corresponding dialkene; and hydrogenating the diol product to form the corresponding aniline. The 2,6 disubstituted anilines can be used to produce N-Heterocyciic Carbenes (NHCs). The NHCs can find application in various fields such as organic synthesis, catalysis and macromolecular chemistry. Palladium catalysts containing the NHCs are also described.

Large yet flexible N-heterocyclic carbene ligands for palladium catalysis

A straightforward and scalable eight-step synthesis of new N-heterocyclic carbenes (NHCs) has been developed from inexpensive and readily available 2-nitro-m-xylene. This process allows for the preparation of a novel class of NHCs coined ITent ("Tent" for "tentacular") of which the well-known IMes (N,N′-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene), IPr (N,N′-bis(2,6-di(2-propyl)phenyl)imidazol-2-ylidene) and IPent (N,N′-bis(2,6-di(3-pentyl)phenyl)imidazol-2-ylidene) NHCs are the simplest and already known congeners. The synthetic route was successfully used for the preparation of three members of the ITent family: IPent (N,N′-bis(2,6- di(3-pentyl)phenyl)imidazol-2-ylidene), IHept (N,N′-bis(2,6-di(4-heptyl) phenyl)imidazol-2-ylidene) and INon (N,N′-bis(2,6-di(5-nonyl)phenyl) imidazol-2-ylidene). The electronic and steric properties of each NHC were studied through the preparation of both nickel and palladium complexes. Finally the effect of these new ITent ligands in Pd-catalyzed Suzuki-Miyaura and Buchwald-Hartwig cross-couplings was investigated. Tentacular NHCs: A straightforward, scalable eight-step synthesis of N-heterocyclic carbenes (NHCs) has been developed using inexpensive and readily available 2-nitro-m-xylene, allowing the preparation of a class of NHCs designated ITent ("Tent" for "tentacular"). The electronic and steric properties of each NHC were studied through the preparation of both nickel and palladium complexes, and the effect of these new ITent ligands in Pd-catalyzed Suzuki-Miyaura and Buchwald-Hartwig cross-couplings was investigated.

Agricultural sulfonamides

This invention relates to novel N-(heterocyclicaminocarbonyl)arylsulfonamides in which the aryl radical is substituted by two carboxyl radicals. The compounds have utility as herbicides.