57055-82-0 Usage
Description
4-(4-Morpholinobutylthio)phenol, also known as MoTP (57055-82-0), is a chemical compound that specifically targets and eliminates zebrafish larval melanocytes. Its melanocytotoxicity is dependent on tyrosinase activity, making it a valuable tool for studying melanocyte stem cell regeneration, recruitment, and maintenance.
Uses
Used in Melanocyte Research:
4-(4-Morpholinobutylthio)phenol is used as a research tool for investigating melanocyte stem cell regeneration, recruitment, and maintenance in zebrafish larvae. Its ability to selectively ablate melanocytes allows researchers to gain insights into the mechanisms underlying melanocyte development and function.
Used in Melanoma Research:
4-(4-Morpholinobutylthio)phenol is used as a research agent for studying the mechanisms of melanoma development and progression. Its melanocytotoxicity can help researchers understand the role of tyrosinase activity in melanoma and potentially identify novel therapeutic targets for melanoma treatment.
Used in Drug Development:
4-(4-Morpholinobutylthio)phenol is used as a lead compound in the development of new drugs targeting melanocyte-related disorders, such as melanoma and pigmentation disorders. Its selective toxicity towards melanocytes and dependence on tyrosinase activity make it a promising candidate for the development of targeted therapies.
Used in Cosmetics Industry:
4-(4-Morpholinobutylthio)phenol is used as an active ingredient in cosmetic products for skin lightening and pigmentation regulation. Its ability to modulate melanocyte activity can help reduce hyperpigmentation and promote an even skin tone.
References
1) Yang et al. (2006), Small molecule-induced ablation and subsequent regeneration of larval zebrafish melanocytes; Development, 133 3563
2) Yang et al. (2007), Mutations in gfpt1 and skiv2I2 cause distinct stage-specific defects in larval melanocyte regeneration in zebrafish; PLoS Genet., 3 e88
3) Hultman et al. (2009), Defects in ErbB-dependent establishment of adult melanocyte stem cells reveal independent origins for embryonic and regeneration melanocytes; PLoS Genet., 5 e1000544
4) Hultman et al. (2010), Differential contribution of direct-developing and stem cell-derived melanocytes to the zebrafish larval pigment pattern; Dev. Biol., 337 425
5) Hultman et al. (2008), Small molecule modifier screen for kit-dependent functions in zebrafish embryonic melanocytes; Zebrafish, 5 279
Check Digit Verification of cas no
The CAS Registry Mumber 57055-82-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,0,5 and 5 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 57055-82:
(7*5)+(6*7)+(5*0)+(4*5)+(3*5)+(2*8)+(1*2)=130
130 % 10 = 0
So 57055-82-0 is a valid CAS Registry Number.
57055-82-0Relevant articles and documents
Method for inhibiting ADP-induced platelet aggregation using phenylthioalkylamines
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, (2008/06/13)
A method for inhibiting blood platelet aggregation in a mammal by administering internally to the mammal an effective amount of a phenylthio(sulfinyl or sulfonyl)alkylamine compound or a pharmaceutically-acceptable salt thereof.
