Journal of Medicinal Chemistry p. 1244 - 1250 (1988)
Update date:2022-08-04
Topics:
Katz, Alan H.
Demerson, Christopher A.
Shaw, Chia-Cheng
Asselin, Andre A.
Humber, Leslie G.
et al.
The synthesis of cis-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)pyrano<3,4-b>indole-1-acetic acid, pemedolac (USAN), is described.This compound has been found to be a potent analgesic agent in primary screening.Pemedolac has been resolved and the active (+)-enantiomer assigned a 1S,4R absolute configuration on the basis of a crystallographic analysis of its (S)-(-)-borneol ester.
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