571168-88-2

Upstream product

• 53937-03-4 N‐methyl‐4‐benzyloxy‐2‐pyridone 
• 53937-02-3 4-(benzyloxy)pyridin-2(1H)-one 
• 100-39-0 benzyl bromide 
• 626-03-9 4-hydroxy-2-pyridone 

Downstream Products

• 571168-94-0 4-(4-benzyloxy-1-methyl-2-oxo-1,2-dihydro-pyridin-3-ylethynyl)-benzoic acid methyl ester 
• 571168-95-1 4-benzyloxy-1-methyl-3-phenylethynyl-2-pyridone 
• 571168-96-2 4-benzyloxy-3-hexynyl-1-methyl-2-pyridone 
• 571169-08-9 3-(4-fluorophenyl)-7-methyl-2-phenyl-7H-furo[2,3-b]pyridin-4-one 

Relevant academic research and scientific papers

Palladium-mediated three-component synthesis of furo[2,3-b]pyridones by one-pot coupling of 3-lodopyridones, alkynes, and organic halides

(Matrix presented) The one-pot assembly of 4-alkoxy-3-iodo-2-pyridones, terminal alkynes, and organic halides has been achieved by integration of two sequential palladium-mediated cross-coupling reactions - Sonogashira and Wacker-type heteroannulation pro

HETEROCYCLIC WDR5 INHIBITORS AS ANTI-CANCER COMPOUNDS

The present invention provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof; (I) which are inhibitors of WDR5. The present invention also provides pharmaceutical compositions comprising such compounds, compositions comprising such compounds with an additional therapeutic agent and the therapeutic uses of such compounds.