57151-38-9

Upstream product

• 67-56-1 methanol 
• 50882-23-0 α'-nitro-4-methoxy-trans-stilbene 
• 4314-68-5 3-(4-methoxyphenyl)-2-phenylpropionic acid 
• 622-42-4 1-nitro-1-phenylmethane 
• 24845-40-7 2-(4-methoxyphenyl)acetophenone 
• 1694-19-5 p-methoxystilbene 
• 123-11-5 4-methoxy-benzaldehyde 
• 71-43-2 benzene 
• 4693-91-8 4-methoxyphenyl-acetic chloride 

Downstream Products

• 34492-35-8 C₃₄H₄₀Cl₂N₃O₂PS 
• 135192-20-0 trans-Pt(NH3)Cl2(2-(4-methoxyphenyl)-1-phenylethylamine) 
• 135192-20-0 cis-Pt(NH3)Cl2(2-(4-methoxyphenyl)-1-phenylethylamine) 
• 618-36-0 rac-methylbenzylamine 
• 131475-31-5 N-(2,2-diethoxyethyl)amino-2-p-methoxyphenyl-1-phenylethane 
• 57151-23-2 1-cycloheptyl-4-[2-(4-methoxy-phenyl)-1-phenyl-ethyl]-piperazine 
• 57151-28-7 1-(2-methoxy-phenyl)-4-[2-(4-methoxy-phenyl)-1-phenyl-ethyl]-piperazine 

Relevant academic research and scientific papers

10,5-(Iminomethano)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene and derivatives. Potent PCP receptor ligands

IDDC (3, 10,5-(iminomethano)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene) and a series of substituted derivatives were synthesized and evaluated in vitro for their ability to displace tritiated MK-801 ([3H]-2) from its specific binding site in guinea pig brain homogenate. Substitution at the 3- position of 3 with bromine, chlorine, and fluorine led to increased binding affinity. In contrast, substitution of donor groups at the 3-position gave decreased binding affinities, as did all substitutions at the 7-position and on nitrogen. Where racemic mixtures were resolved, the (+)-optical antipodes were more active than their enantiomers or racemates. The most active ligand found in this study was (+)-13e (IC50 = 15.5 ± 4.5 nM). The affinity of (+)-13e for the PCP receptor makes it among the most potent ligands known. In vitro neuroprotection was demonstrated by 3, (+)-3, and (+)-6 (N-Me-IDDC) against glutamate-induced cell death in rat hippocampal cells.

Regiochemistry on Photoamination of Stilbene Derivatives with Ammonia via Electron Transfer

The regiochemistry of photoamination of 1,2-diarylethene (1) with ammonia in the presence of p-dicyanobenzene (DCNB) has been investigated.The photoamination of stilbene and p,p'-dimethoxystilbene gave 1-amino-1,2-diphenylethane and 1-amino-1,2-bis(p-methoxyphenyl)ethane, respectively.The photoamination of unsymmetric 1-aryl-2-phenylethene having an alkoxy group on the para position occurred selectively to give 1-amino-2-aryl-1-phenylethane.On the other hand, the photoamination of 1-aryl-2-phenylethene having a methyl and chloro group on the para position or methoxy group on the meta and ortho positions gave both 1-amino-2-aryl-1-phenylethane and 1-amino-1-aryl-2-phenylethane.The regiochemistry is related with the distribution of positive charge in the cation radicals of 1 generated from photochemical electron transfer to DCNB.