57165-02-3Relevant academic research and scientific papers
URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C
-
Page/Page column 191, (2009/04/25)
Present application relates to the compounds of formula I useful to treat hepatitis C (HCV) infections. In the structure of the disclosed compounds is the uracil or thymine derivative linked via a phenylene into either fused 2-ring cyclic system (R6) or alternatively via additional two-atom linker (L) to a 5-6 membered monocycle (R6). Application further discloses polymorphs and pseudopolymorphs of two specific compounds: N-(6(3-t-butyl-5-(2>4-dioxo-3,4-dihydropyrimidin-1 (2H)- y!)2-methoxy-phenyl)naphthalen-2-yl)methanesulfonamide and (E)-N-(4(3-t- butyl-5-(2,4-dioxo-3)4-dihydropyrimidin-1 (2H)-yl)2-methoxy-styryl- phenyl)methanesulfonamide.
ANTI-INFECTIVE PYRIMIDINES AND USES THEREOF
-
Page/Page column 120, (2009/04/25)
This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
Potential Antitumor Agents. 41. Analogues of Amsacrine with Electron-Donor Substituents in the Anilino Ring
Atwell, Graham J.,Rewcastle, Gordon W.,Denny, William A.,Cain, Bruce F.,Baguley, Bruce C.
, p. 367 - 372 (2007/10/02)
The preparation and antitumor activity of a series of 3'-alkylamino and 3'-dialkylamino analogues of amsacrine are reported.The results support previous work suggesting that the presence of electron-donating groups in the 3'-position of the anilino ring s
