88413-07-4Relevant academic research and scientific papers
Ortho-phenylenediamine compounds
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, (2008/06/13)
Compounds represented by the general formula (I): STR1 in which R1 represents STR2 A and B each represent H or a lower alkane optionally substituted with amino and/or hydroxyl functions, except that A and B are not both H; R3 represe
Potential Antitumor Agents. 48. 3'-Dimethylamino Derivatives of Amsacrine: Redox Chemistry and in Vivo Tumor Activity
Atwell, Graham J.,Rewcastle, Gordon W.,Baguley, Bruce C.,Denny, William A.
, p. 652 - 658 (2007/10/02)
Structure-activity relationships for a series of acridine-substituted 3'-N(CH3)2 derivatives of the clinical antileukemic drug amsacrine (1) are reported.The parent (unsubstituted) compound 3 has activity against the Lewis lung solid tumor that is superior to amsacrine(1), the new clinical amsacrine analogue 4, and the recently developed 3'-NHCH3 derivative 2.Although the compounds generally bind less well to DNA and are less dose potent in vivo than either their amsacrine (3'-OCH3) or 3'-NHCH3 analogues, they show very high levels of antitumor activity, with the 4-OCH3 derivative capable of effecting 100percent cures of the Lewis lung solid tumor.The broad structure-activity relationships for acridine substitution more closely resemble those of the amsacrine than the 3'-NHCH3 series, with 4-substituted and 4,5-disubstituted compounds showing the highest activity.
Potential Antitumor Agents. 47. 3'-Methylamino Analogues of Amsacrine with in Vivo Solid Tumor Activity
Atwell, Graham, J.,Baguley, Bruce C.,Finlay, Graeme J.,Rewcastle, Gordon W.,Denny, William A.
, p. 1769 - 1776 (2007/10/02)
Replacement of the 3'-methoxy group of the clinical antileukemic agent amsacrine (1) with a 3'-methylamino group provides a compound (3) with a broader spectrum of action, including in vivo activity against experimental solid tumors.The synthesis, physico
Substituted o-phenylenediamine acridine compounds having antitumor activity
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, (2008/06/13)
Compounds represented by the general formula (I): STR1 in which R1 represents STR2 A and B each represent H or a lower alkane optionally substituted with amino and/or hydroxyl functions, except that A and B are not both H; R3 represe
Potential Antitumor Agents. 41. Analogues of Amsacrine with Electron-Donor Substituents in the Anilino Ring
Atwell, Graham J.,Rewcastle, Gordon W.,Denny, William A.,Cain, Bruce F.,Baguley, Bruce C.
, p. 367 - 372 (2007/10/02)
The preparation and antitumor activity of a series of 3'-alkylamino and 3'-dialkylamino analogues of amsacrine are reported.The results support previous work suggesting that the presence of electron-donating groups in the 3'-position of the anilino ring s
