57181-38-1Relevant articles and documents
Complexes of Copper(II) Chloride with Diaryl-4,4′-Bisdiazonium Dichlorides, Their Transformation into 4,4-Chlorodiaryls and Reaction with Olefins
Obushak,Lyakhovich,Fedorovich,Ganushchak
, p. 1471 - 1476 (2007/10/03)
Diaryl-4,4′-bisdiazonium dichlorides react with olefins in CuCl2 presence to form 4,4′-bisdiazoniumdiaryl tetrachlorocuprates(II) as intermediates. The method of synthesis of these stable complex diazonium salts under ordinary conditions has been worked out. They decompose in polar solvents at room temperature to form 4,4′-dichlorodiaryls in high yield. In the presence of olefins (compounds containing a X = Y bond, acrylates and metacrylates, acrylonitrile, styrene, 1,3-butadiene) they decompose forming adducts, products of chloroarilation of the enumerated substrates to double bond consuming one or two diazogroups. 4-Styryl-4′-chlorodiaryls, the products of arylation by one diazogroup, were obtained from styrene.
Studies on antihyperlipidemic agents. I. Synthesis and hypolipidemic activities of phenoxyphenyl alkanoic acid derivatives
Kawamatsu,Saraie,Imamiya,Nishikawa,Hamuro
, p. 454 - 458 (2007/10/02)
The alkanoic acids containing phenoxyphenyl moiety at ω-position were prepared and tested for hypolipidemic property. Some of the compounds showed hypoglycemic activity besides hypolipolipidemic one. Further study on the selected compound, 3-[4-(4-chlorophenoxy)benzoyl]propionic acid (8) revealed that it increased insulin sensitivity of adipose tissue of obese and diabetic mice (KKA(y)). The structure-activity relationship was discussed briefly.
