57186-64-8

Basic information

• Product Name: Benzene, 1-chloro-4-(2-iodoethyl)-
• Synonyms: 2-(4-chlorophenyl)ethyl iodide;1-iodo-2-(4-chlorophenyl)ethane;1-chloro-4-(2-iodoethyl)benzene;p-chlorophenethyl iodide;4-chloro-phenethyl iodide;1-Chloro-4-(2-iodo-ethyl)-benzene;4-Chlor-phenaethyljodid
• CAS NO: 57186-64-8
• Molecular Formula: C8H8ClI
• Molecular Weight: 266.509
• Mol File: 57186-64-8.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 91 - 94 °C (0.6 - 0.7 mmHg)
• CAS DataBase Reference: Benzene, 1-chloro-4-(2-iodoethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-chloro-4-(2-iodoethyl)-(57186-64-8)
• EPA Substance Registry System: Benzene, 1-chloro-4-(2-iodoethyl)-(57186-64-8)

Safety Data

• Hazardous Substances Data: 57186-64-8(Hazardous Substances Data)

Upstream product

• 6948-71-6 toluene-4-sulfonic acid 2-(4-chloro-phenyl)-ethyl ester 
• 80019-71-2 methanesulfonic acid-2-(4-chlorophenyl)ethyl ester 
• 1875-88-3 2-(4-Chlorophenyl)ethanol 
• 52449-43-1 (4-chloro-phenyl)-acetic acid methyl ester 
• 2019-34-3 3-(4-chlorophenyl)propanoic acid 
• 1878-66-6 4-chlorophenylacetic Acid 
• 6529-53-9 1-(2-bromoethyl)-4-chlorobenzene 
• 104-88-1 4-chlorobenzaldehyde 
• 106-39-8 bromochlorobenzene 
• 97946-22-0 1,1-diiodo-2-(p-chlorophenyl)ethene 

Downstream Products

• 1508310-68-6 1-(4-chlorophenethyl)-1H-indol-5-amine 
• 1508310-48-2 N-(1-(4-chlorophenethyl)-1H-indol-5-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide 
• 167504-31-6 (+/-)-5-(4'-chlorophenethyl)-2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinoline 
• 167504-26-9 (+/-)-5-(4'-chlorophenethyl)-5,6,7,8-tetrahydroisoquinoline 
• 10270-28-7 4-(2-(4'-chlorophenyl)ethyl)benzonitrile 
• 4531-89-9 2--1-<(4-trimethyl-silyl)-phenyl>-aethan 
• 928776-05-0 4-[2-(4-chloro-phenyl)-ethyl]-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbaldehyde 

Relevant articles and documents

Allyl 4-Chlorophenyl Sulfone as a Versatile 1,1-Synthon for Sequential α-Alkylation/Cobalt-Catalyzed Allylic Substitution

Despite their unique potential as rare 1,1-dipole synthons, allyl sulfones are rarely used in target-oriented syntheses, likely due to the lack of a general catalytic method for their branch-selective allylic substitution. Herein, we identified allyl 4-chlorophenyl sulfone as a versatile linchpin for both base-mediated α-derivatization and subsequent cobalt-catalyzed allylic substitution. The sequential transformations allow for highly regioselective access to branched allylic substitution products with a variety of aliphatic side chains. The photoredox-enabled cobalt catalysis is indispensable for achieving high yields and regioselectivity for the desulfonylative substitution in contrast to traditional metal-catalyzed protocols, which lead to inferior outcomes in the corresponding transformations.

One-Pot Transformation of Aliphatic Carboxylic Acids into N-Alkylsuccin-imides with NIS and NCS/NaI

Primary aliphatic carboxylic acids were treated with N-iodosuccinimide (NIS) in 1,2-dichloroethane to form the corresponding alkyl iodides under warming conditions. Based on these results, those aliphatic carboxylic acids were treated with NIS, followed by the reaction with K2CO3to give the corresponding N-alkylsuccinimides in good yields in one pot. Moreover, those aliphatic carboxylic acids were treated with N-chlorosuccinimide (NCS) and NaI, followed by the reaction with K2CO3to provide the corresponding N-alkylsuccinimides in good to moderate yields in one pot. By using the present method, successive treatment of primary aliphatic carboxylic acids (10 mmol) with NIS, K2CO3, and then hydrazine provided the corresponding decarboxylated primary amines in good yield.

Discovery of tertiary amine and indole derivatives as potent RORγt inverse agonists

A novel series of tertiary amines as retinoid-related orphan receptor gamma-t (RORγt) inverse agonists was discovered through agonist/inverse agonist conversion. The level of RORγt inhibition can be enhanced by modulating the conformational disruption of H12 in RORγt LBD. Linker exploration and rational design led to the discovery of more potent indole-based RORγt inverse agonists.