57238-67-2Relevant academic research and scientific papers
Enantioselective Radical Construction of 5-Membered Cyclic Sulfonamides by Metalloradical C-H Amination
Hu, Yang,Lang, Kai,Li, Chaoqun,Gill, Joseph B.,Kim, Isaac,Lu, Hongjian,Fields, Kimberly B.,Marshall, McKenzie,Cheng, Qigan,Cui, Xin,Wojtas, Lukasz,Zhang, X. Peter
supporting information, p. 18160 - 18169 (2019/11/19)
Both arylsulfonyl and alkylsulfonyl azides can be effectively activated by the cobalt(II) complexes of D2-symmetric chiral amidoporphyrins for enantioselective radical 1,5-C-H amination to stereoselectively construct 5-membered cyclic sulfonami
Nickel-catalyzed allylic substitution of simple alkenes
Matsubara, Ryosuke,Jamison, Timothy F.
supporting information; experimental part, p. 1860 - 1875 (2012/02/02)
This report describes a nickel-catalyzed allylic substitution process of simple alkenes whereby an important structural motif, a 1,4-diene, was prepared. The key to success is the use of an appropriate nickel-phosphine complex and a stoichiometric amount of silyl triflate. Reactions of 1-alkyl-substituted alkenes consistently provided 1,1-disubstituted alkenes with high selectivity. Insight into the reaction mechanism as well as miscellaneous application of the developed catalytic process is also documented.
Nickel-catalyzed allylic substitution of simple alkenes
Matsubara, Ryosuke,Jamison, Timothy F.
supporting information; experimental part, p. 6880 - 6881 (2010/07/05)
Nickel-catalyzed intermolecular allylic substitution of simple alkenes (ethylene and alpha olefins) is described. This method is the first catalytic intermolecular process for direct allylation of nonconjugated, nonstrained simple alkenes. Catalyst loadings as low as 2.5 mol % Ni afford the desired product in high yield in both gram-scale and smaller scale coupling reactions.
A general model for selectivity in olefin cross metathesis
Chatterjee, Arnab K.,Choi, Tae-Lim,Sanders, Daniel P.,Grubbs, Robert H.
, p. 11360 - 11370 (2007/10/03)
In recent years, olefin cross metathesis (CM) has emerged as a powerful and convenient synthetic technique in organic chemistry; however, as a general synthetic method, CM has been limited by the lack of predictability in product selectivity and stereoselectivity. Investigations into olefin cross metathesis with several classes of olefins, including substituted and functionalized styrenes, secondary allylic alcohols, tertiary allylic alcohols, and olefins with α-quaternary centers, have led to a general model useful for the prediction of product selectivity and stereoselectivity in cross metathesis. As a general ranking of olefin reactivity in CM, olefins can be categorized by their relative abilities to undergo homodimerization via cross metathesis and the susceptibility of their homodimers toward secondary metathesis reactions. When an olefin of high reactivity is reacted with an olefin of lower reactivity (sterically bulky, electron-deficient, etc.), selective cross metathesis can be achieved using feedstock stoichiometries as low as 1:1. By employing a metathesis catalyst with the appropriate activity, selective cross metathesis reactions can be achieved with a wide variety of electron-rich, electron-deficient, and sterically bulky olefins. Application of this model has allowed for the prediction and development of selective cross metathesis reactions, culminating in unprecedented three-component intermolecular cross metathesis reactions.
Unsymmetrical cyclic diamine compound
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, (2008/06/13)
A cyclic diamine compound of formula (1): wherein A is (CH2)n, (CH2)n—CH═CH, CO—(CH2)n or CO—(CH2)n—CH═CH, in which n is a number of 0 to 3; Z represents a formula (2) or (3): in which R1, R2, R4, R5 and R6 are individually a hydrogen atom, alkyl group, alkoxy group, halogen atom or nitro group; R3 is a hydrogen atom, alkyl group, alkoxy group, halogen atom, nitro group, naphthyl group, or phenyl group which may be substituted by 1 to 3 substituents selected from the group consisting of alkyl groups, alkoxy groups, halogen atoms, a nitro group and a phenyl group; and X and Y are individually CH or a nitrogen atom; and m is 1 or 2; an acid-addition salt thereof, or a hydrate thereof, and a medicine containing such a compound.
Mild and efficient aryl-alkenyl coupling via Pd(II) catalysis in the presence of oxygen or Cu(II) oxidants
Parrish, Jay P.,Jung, Young Chun,Shin, Seung Il,Jung, Kyung Woon
, p. 7127 - 7130 (2007/10/03)
We report herein a mild and efficient method for carbon-carbon bond formation between aryl stannanes and olefins via Pd(II) catalysis in the presence of oxygen or Cu(II) oxidants as a reoxidant. The process allows reactions between various olefins and aryl stannanes of varying electron density. Coupling methods under these oxidation conditions are comparatively described, and the benefits and limitations are also discussed.
Carbon-carbon double-bond formation from the reaction of organozinc reagents with aldehydes catalyzed by a nickel(II) complex
Wang, Jin-Xian,Fu, Ying,Hu, Yulai
, p. 2757 - 2760 (2007/10/03)
Stereoselective alkenylated compounds are formed from the reaction of organozinc halides and aldehydes (see scheme; FG = functional group). Under mild conditions, and in the presence of a silylating agent, the Ni-catalyzed procedure gives E-alkenes and E-
Studies on the wittig reaction (XV): A direct preparation of ω-unsaturated bromides via solid/liquid transferred Wittig reactions of ω-bromoalkyltriphenyl phosphonium Salts with aldehydes
Ding,Shi,Xiao,Huang,Wu
, p. 3235 - 3239 (2007/10/02)
A new approach to the synthesis of ω-unsaturated bromides was proposed using solid/liquid transferred Wittig reactions between ω-bromoalkyltripheny phosphonium Salt and aldehydes.
The Triplex Diels-Alder Reaction: Intramolecular Cycloaddition of Phenyl-Substituted Alkenes to 1,3-Dienes
Woelfle, Ingrid,Chan, Samantha,Schuster, Gary B.
, p. 7313 - 7319 (2007/10/02)
The triplex Diels-Alder reaction of dienes and styrene-like dienophiles that are covalently linked with a flexible alkyl chain was investigated.Sensitization with 9,10-dicyanoanthracene in benzene solution leads to good yields of adducts when the di
