57286-93-8

Usage

Uses

Used in Pharmaceutical Industry:
(1R)-1-(4-Methoxyphenyl)-2-(methylamino)ethanol is used as an active pharmaceutical ingredient for the development of drugs targeting various medical conditions. Its unique structure and optical activity make it a promising candidate for drug discovery and development.
Used in Chemical Research:
(1R)-1-(4-Methoxyphenyl)-2-(methylamino)ethanol is used as a research tool in the field of organic chemistry, particularly in the study of phenethylamine alkaloids and their potential applications in various chemical and biological processes.
Used in Material Science:
(1R)-1-(4-Methoxyphenyl)-2-(methylamino)ethanol may be utilized in the development of novel materials with specific optical, electronic, or structural properties due to its unique molecular structure and optical activity.
Used in Analytical Chemistry:
(1R)-1-(4-Methoxyphenyl)-2-(methylamino)ethanol's distinct ultraviolet spectrum can be employed in analytical chemistry for the identification and quantification of similar compounds in complex mixtures, as well as for the development of new analytical methods and techniques.

References

Ranieri, McLaughlin,J. Org. Chem., 41, 319 (1976)

Upstream product

• 117712-19-3 1-(4-methoxy-phenyl)-2-methylamino-ethanone 
• 123-11-5 4-methoxy-benzaldehyde 
• 97070-73-0 (R)-(+)-α-Hydroxy-4-methoxybenzeneacetonitrile 
• 142429-14-9 (R)-(+)-<(2-methoxy-iso-propyl)oxy>-4-methoxybenzeneacetonitrile 
• 74-89-5 methylamine 
• 131043-85-1 (4R,5R)-5-(4-Methoxy-phenyl)-4-(toluene-4-sulfonyl)-4,5-dihydro-oxazole 
• 104383-29-1 methyl (S)-α-hydroxy-(4-methoxyphenyl)acetate 
• 87920-02-3 4-methoxy-L-mandelic acid-methylamide 
• 186581-53-3 diazomethane 
• 532-80-9 (+)-Synephrine 

Relevant academic research and scientific papers

Method for synthesizing chiral alpha-amino alcohol compound

The invention discloses a method for synthesizing a chiral alpha-amino alcohol compound. The method comprises the following steps: sequentially adding an iron catalyst, a ligand, ketone, an organic solvent and silane into a reaction system at 20-30 DEG C in a nitrogen atmosphere, then stirring the obtained mixture, and carrying out column chromatography separation on the obtained product to obtain a product, namely chiral alpha-amino alcohol. According to the invention, the most high-yield iron catalyst in earth crust is used, and cheap silane (PMHS, 500 g/298 yuan) is adopted as a reducing agent, so the asymmetric reduction reaction of alpha-amino ketone can be efficiently achieved under mild conditions so as to obtain the high-yield optically-active chiral alpha-amino alcohol compound; and moreover, through the creative labor of the inventor, reaction yield can reach 99%, and meanwhile, the content of the target product in the generated reaction product is 99%.

A one-pot reduction-transimition-reduction synthesis of N-substituted β-ethanolamines from cyanohydrins

An efficient (74% - 97% yield) three-step one-pot synthesis of (R)-Halostachine and analogues from O-protected optically active cyanohydrins is described. The reaction sequence involves a DIBAL reduction of the nitrile to an imine, transimination to a secondary imine and sodium borohydride reduction to the corresponding N-substituted β-ethanolamine. Both O-protected as well as unprotected reaction products can be obtained.

The Asymmetric Aldol Reaction of Tosylmethyl Isocyanide and Aldehydes Catalyzed by Chiral Silver(I) Complexes

The asymmetric aldol reaction of tosylmethyl isocyanide and aldehydes in the presence of 1 mol percent of chiral silver(I) catalysts gave optically active 5-alkyl-4-tosyl-2-oxazolines (up to 86percent ee), which were converted to optically active α-alkyl-β-(N-methylamino)ethanols by LiAlH4 reduction.