57296-63-6

Usage

InChI:InChI=1/C18H14Cl2O4/c1-18(11-5-3-2-4-6-11)8-10-7-12(24-9-13(21)22)15(19)16(20)14(10)17(18)23/h2-7H,8-9H2,1H3,(H,21,22)

Upstream product

• 57509-50-9 6,7-dichloro-2,3-dihydro-5-hydroxy-2-methyl-2-phenyl-1H-inden-1-one 
• 105-36-2 ethyl bromoacetate 
• 67995-02-2 (1-oxo-2-phenyl-6,7-dichloro-5-indanyloxy)acetic acid 
• 74-88-4 methyl iodide 
• 88494-66-0 (S)-(+)-6,7-dichloro-5-methoxy-2-methyl-2-phenyl-1-indanone 
• 57296-65-8 (S)-6,7-Dichloro-5-hydroxy-2-methyl-2-phenyl-indan-1-one 
• 88440-75-9 ((S)-6,7-Dichloro-2-methyl-1-oxo-2-phenyl-indan-5-yloxy)-acetic acid ethyl ester 
• 59043-83-3 2,3-dichloro-4-phenylacetylanisole 
• 57713-17-4 2-methyl-2-phenyl-5-methoxy-6,7-dichloro-1-indanone 
• 57296-59-0 2,3-dichloro-4-(2-phenylacryloyl)-anisole 
• 53107-36-1 1-(2,3-dichloro-4-methoxyphenyl)-2-bromo-2-methyl-1-propanone 
• 60769-26-8 2-Phenyl-5-methoxy-6,7-dichloro-1-indanone 
• 67976-22-1 2-phenyl-5-hydroxy-6,7-dichloro-1-indanone 
• 53107-37-2 1-(2,3-dichloro-4-methoxyphenyl)-2-methylene-1-propanone 

Downstream Products

• 66015-32-5 [1-oxo-2-methyl-2-(4-sulfamoylphenyl)-6,7-dichloro-5-indanyloxy]acetic acid 

Relevant academic research and scientific papers

(1-Oxo-2-aryl or thienyl-2-substituted-5-indanyloxy (or thio) alkanoic acids, and derivatives thereof

[1-Oxo-2-aryl or thienyl-2-substituted-5-indanyloxy (or thio)]aklanoic acid, derivatives thereof, their salts, esters and amides are disclosed. The products display a dual pharmaceutical utility in that they exhibit diuretic, saluretic and uricosuric activity. Also disclosed are processes for the preparation of such [1-oxo-2-aryl or thienyl-2-substituted-5-indanyloxy (or thio)]alkanoic acids, pharmaceutical compositions comprising therapeutically effective amounts of such compounds and methods of treatment comprising administering such compounds and compositions.

[1-Hydroximino-2,2-disubstituted-5-indanyloxy-(or thio)]alkanoic acids

[1-Hydroximino-2,2-disubstituted-5-indanyloxy-(or thio)]alkanoic acids and their salt, ester, anhydride, amide and 5-tetrazolyl derivatives are disclosed. The products display a dual pharmaceutical utility in that they exhibit diuretic, saluretic and uricosuric activity. The acid products are prepared by treating a 1-oxo-2,2-disubstituted-5-indanyloxy(or thio)alkanoic acids or derivatives thereof with hydroxylamine in the presence of a base.